Neuroscience 2000 Abstract
| Presentation Number: | 483.10 |
|---|---|
| Abstract Title: | A rodent model of adolescent drug progression. |
| Authors: |
Morin, L.*1
; Hernandez, J.1
; Boal, J.1
; Siciliano, D.1
; Cruise, M.1
; Smith, R. F.1
1Dept Psychol, George Mason Univ, Fairfax, VA |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 143. Drugs of abuse: alcohol, barbiturates and benzodiazepines |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 145. Drugs of abuse: cocaine |
| Session: |
483. Drugs of abuse: alcohol III Poster |
| Presentation Time: | Tuesday, November 7, 2000 9:00 AM-10:00 AM |
| Location: | Hall G-J |
| Keywords: | Cocaine, Alcohol, Addiction |
Progression from drugs such as alcohol and tobacco to marijuana and 'harder' drugs is common in adolescents. To assess whether progression occurs in an adolescent rodent model, we dosed rats with 5% or 10% alcohol (EtOH), or water under pair-watered or free intake conditions, from PD21 to PD70 [designated PPA, pre- and peri-adolescent]. Fluid was available 1 hr daily, and both 5% and 10% EtOH induced high SECs. After dosing was concluded, we assessed carryover effects to later cocaine administration for three potential modes of carryover. Direct carryover effects were seen: PPA 5% EtOH significantly increased adult IV cocaine self-administration, 5% and 10% decreased cocaine conditioned place preference (reported at Neuroscience '99), and 5% and 10% altered cocaine-stimulated motor activity in a gender-specific manner. Acute withdrawal carrover effects were not observed on tests of cocaine-induced activity and schedule-induced polydipsia, with repeated testing during withdrawal from alcohol. Drug-associated cue effects were assessed, after PPA dosing with distinctive visual, auditory, and olfactory cues. Adult testing was conducted both in the presence and in the absence of these cues. Cues tended to attenuate cocaine-induced locomotor activity. In summary, rats demonstrate behavior consistent with adolescent drug progression. Direct carryover effects were found on every measure assessed, and there was a tendency for drug-associated cues to also affect later cocaine-associated behavior. These data suggest that biological mechanisms may also underlie drug progression in humans.
Supported by NIDA DA11833-01.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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