Neuroscience 2002 Abstract
| Presentation Number: | 498.3 |
|---|---|
| Abstract Title: | MRI evidence of reduced cortical gray matter in familial bipolar I disorder. |
| Authors: |
Deicken, R. F.*1,3
; Deodhar, D.1,3
; Kwon, A.1
; Rogers, L. J.1,2
; Cardenas, V. A.2,4
1Psychiatry, Veterans Affairs Medical Center, San Francisco, CA 2Magnetic Resonance Unit, Veterans Affairs Medical Center, San Francisco, CA 3Psychiatry, University of California, San Francisco, San Francisco, CA 4Radiology, University of California, San Francisco, San Francisco, CA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective Disorders |
| Session: |
498. Psychiatric disorders: affective disorders--imaging studies Poster |
| Presentation Time: | Tuesday, November 5, 2002 10:00 AM-11:00 AM |
| Location: | Hall A2-B3 Z-32 |
| Keywords: | BRAIN IMAGING, NEUROIMAGING, CEREBRAL CORTEX |
Despite neuropathological evidence for significant neuronal and glial cell reductions in specific cortical regions in bipolar disorder, MRI studies have not consistently demonstrated either global or regional cortical gray matter reductions. Several MRI studies have suggested that brain abnormalities may be more prominent in familial mood disorders. Therefore, this study examined DSE and MP-RAGE MRI images of 20 familial bipolar I subjects (age 38.9 ± 9.4 years) and 45 control subjects (age 34.6 ± 10.4 years) utilizing quantitative MRI tissue segmentation and Talairach-atlas based volumetric techniques. ANCOVA with age, sex, and intracranial volume as covariates was used for statistical analysis. The bipolar I disorder group demonstrated significantly increased sulcal (p=0.010) and ventricular CSF (p=0.015), as well as decreased white matter (p=0.043) and cortical gray matter(p=0.009). To further investigate the cortical gray matter reduction, Talairach atlas-based regional voluming revealed significantly decreased volumes of the anterior cingulate cortex (Brodmann 24), right superior temporal gyrus (Brodmann 22), and inferior frontal cortex (Brodmann 44,45). Strong trends for reductions were noted in the dorsolateral prefrontal (Brodmann 9,10,46), left orbitofrontal (Brodmann 10,11,47) and left entorhinal (Brodmann 28) cortices. These results suggest that volume loss preferentially affects certain regions of the cortex in bipolar I disorder, and are consistent with the post-mortem findings of cortical neuronal and glial abnormalities.
Supported by NIH Grant MH62102
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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