Neuroscience 2004 Abstract
| Presentation Number: | 431.6 |
|---|---|
| Abstract Title: | Neural mechanism of central nervous system fatigue. |
| Authors: |
Tanaka, M.*1
; Sadato, N.2
; Okada, T.2
; Mizuno, K.1
; Sasabe, T.1,3
; Saito, D. N-.2
; Onoe, H.
; Kuratsune, H.
; Watanabe, Y.1
1Physiol, Osaka City Univ Grad Sch Med, Osaka, Japan 2Japan, 1-4-3 Asahimachi, Abeno-ku, 545-8585, 3Div. of Cerebral Integration, Dept. of Cerebral Res., 1-4-3 Asahimachi, Abeno-ku, 545-8585, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Brain Blood Flow, Metabolism, and Homeostasis -- Functional Imaging |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Psychiatric Disorders<br />-- Other |
| Session: |
431. Functional Imaging Poster |
| Presentation Time: | Monday, October 25, 2004 9:00 AM-10:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # II27 |
| Keywords: | fMRI |
To understand the mechanism of central nervous system (CNS) fatigue, we investigated the responsiveness of the brain in chronic fatigue syndrome (CFS) patients and in control subjects by using functional magnetic resonance imaging (fMRI). While the subjects were conducting a fatigue-inducing continual visual search task, the responsiveness of the auditory cortices to transient noise reduction of short duration was simultaneously measured. During the fatigue-inducing period, the responsiveness of the auditory cortices was attenuated more rapidly in the CFS patients than in the control subjects. The attenuation speed of CFS patients was significantly correlated with the subjective fatigue sensation just before the MRI session measured by use of a fatigue visual analogue scale. After the fatigue-inducing session, the decrement of responsiveness in the visual cortices was similar between the 2 groups. Hence, CNS fatigue may be characterized by the attenuation of the responsiveness to stimuli non-specific to the fatigue-inducing task.
Supported by Special Coordination Funds for Promoting Science and Technology from the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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