Neuroscience 2003 Abstract
| Presentation Number: | 414.18 |
|---|---|
| Abstract Title: | Quantitative dt-MRI analysis of the human superior longitudinal fascicle in stroke. |
| Authors: |
Makris, N.*1
; Normandin, J. J.1
; Papadimitriou, G. M.1
; Albaugh, M. D.1
; McInerny, S.1
; Caviness, V. S.1
; Kennedy, D. N.1
1Neurol., Mass Gen. Hosp, Boston, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Trauma -- Brain |
| Session: |
414. Trauma: Brain II Poster |
| Presentation Time: | Monday, November 10, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # LL3 |
| Keywords: |
Objective: The stem of the superior longitudinal fascicle (SLF) was characterized volumetrically and biophysically (in terms of fractional (FI) and lattice anisotropy (LI) indices) in vivo in four patients with left perisylvian ischemic stroke lesions, and in four healthy adult human subjects using DT-MRI. Quantitative analysis was performed anterior to the site of the lesion to assess the integrity and size of SLF, allowing for the identification of potential secondary degeneration changes of this association fiber pathway.
Methods: A Siemens Sonata 1.5 Tesla scanner was used. Scans included MP-RAGE T1 scans and echo-planar diffusion tensor-MRI (DT-MRI). The echo-planar based protocol included diffusion tensor imaging to sample the diffusion tensor, D, using a seven-shot EPI technique with TR=200ms, TE=89ms, 36 averages, image matrix=128x128, voxel size=2x2x2mm3, b=1000s/mm2, 60 contiguous coronal slices for a total acquisition time of approx. 13 min, and a SNR of approx. 40. Custom made software and semi-automatic segmentation procedures were used for the analysis.
Results: Results related to SLF differential right vs. left volumetric reduction in one stroke patient with a left perisylvian temporo-parietal lesion are presented here. We also present the differential right vs. left volumetric comparison in four healthy subjects. In the patient, the left SLF was 44% smaller than the right SLF and the symmetry index was -0.79, indicating a rightward asymmetry. This was not observed in the four healthy subjects, which showed an overall symmetry between the right and left SLF (symmetry index = 0.08).
Conclusion: This preliminary study shows that in stroke patients, the changes due to secondary degeneration of the SLF can be detected and quantified by DT-MRI in terms of volume and biophysical measurements. We expect these types of analyses to be applied in neuroscience of language and language disorders.
Methods: A Siemens Sonata 1.5 Tesla scanner was used. Scans included MP-RAGE T1 scans and echo-planar diffusion tensor-MRI (DT-MRI). The echo-planar based protocol included diffusion tensor imaging to sample the diffusion tensor, D, using a seven-shot EPI technique with TR=200ms, TE=89ms, 36 averages, image matrix=128x128, voxel size=2x2x2mm3, b=1000s/mm2, 60 contiguous coronal slices for a total acquisition time of approx. 13 min, and a SNR of approx. 40. Custom made software and semi-automatic segmentation procedures were used for the analysis.
Results: Results related to SLF differential right vs. left volumetric reduction in one stroke patient with a left perisylvian temporo-parietal lesion are presented here. We also present the differential right vs. left volumetric comparison in four healthy subjects. In the patient, the left SLF was 44% smaller than the right SLF and the symmetry index was -0.79, indicating a rightward asymmetry. This was not observed in the four healthy subjects, which showed an overall symmetry between the right and left SLF (symmetry index = 0.08).
Conclusion: This preliminary study shows that in stroke patients, the changes due to secondary degeneration of the SLF can be detected and quantified by DT-MRI in terms of volume and biophysical measurements. We expect these types of analyses to be applied in neuroscience of language and language disorders.
Supported by ALSA,NARSAD
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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