Neuroscience 2000 Abstract
| Presentation Number: | 461.3 |
|---|---|
| Abstract Title: | MRI-based volumetric analysis of subcortical consequences of stroke. |
| Authors: |
Makris, N.*1
; Sahin, N. T.1
; Bates, J. W.1
; Patti, M. R.1
; Meyer, J. W.1
; Caplan, D. N.1
; Caviness Jr., V. S.1
; Kennedy, D. N.1
1Dept. of Neurology, MGH, Boston, MA |
| Primary Theme and Topics |
H. Other Systems of the CNS - 99. Association cortex and thalamocortical relations |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 136. Ischemia: functional outcome |
| Session: |
461. Association cortex and thalamocortical relations Poster |
| Presentation Time: | Tuesday, November 7, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | THALAMUS*, ISCHEMIA, MORPHOMETRY, CORTEX** |
Introduction: We studied the remote subcortical effects of cortical damage in twenty-one patients affected by stroke due to embolic occlusion of the left middle cerebral artery. We hypothesized that damage of cortical gray matter would result in decrease of volumes in subcortical remote brain areas such as the thalamus or the corpus striatum that are connected to these cortical regions. Methods: The neuroimaging protocol included rapid volumetric homogenization of the magnetic field (shimming) over the entire brain volume and 3D Morphometric images (GE SPGR inversion recovery weighted T1 images). This protocol was performed successfully in twenty-one patients affected by stroke and twenty normal control subjects. Results and Discussion: We observed volumetric reduction of subcortical gray structures in the patients, especially ipsilateral to the cortical lesions. Here we report the raw data for the thalamus as an example of our findings. In the normal control young adults the mean value of the right thalamus is 7.4 cc with a standard deviation (SD) of .62 cc whereas in the patients the right thalamus is 6.5 +/- 1.4 cc which is mildly reduced at the p<.02; presumably there is an age and disease effect. On the other hand the left thalamus in the normals is 7.34 +/-.62 cc whereas in the patients the left thalamus is 5.22 +/- 1.3 cc which is exceedingly different between normals and patients at p<6.2 X 10-7. The asymmetry of this effect is presumably due to a disease related volumetric alteration on the left side. Similar observations in the corpus striatum, hippocampus and amygdala lend evidence to systematic alterations of these deep gray structures in response to cortical insults. These results show the capability to study quantitatively in vivo changes in volume of brain structures following damage of other structures with which these are connected. These classes of analyses would lead to a comprehensive model and a further understanding of human cerebral anatomic connectivity.
Supported by in part, grants from the Fairway Trust, and the Giovanna Armenise-Harvard Foundation for Advanced Scientific Research.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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