Neuroscience 2005 Abstract
| Presentation Number: | 421.5 |
|---|---|
| Abstract Title: | Rewarding properties of concomitant MDMA and THC administration in mice. |
| Authors: |
Robledo, P.*1,2
; Panayi, F.1
; Maldonado, R.1
1Unidad de Neurofarmacologia, Univ. Pompeu Fabra, Barcelona, Spain 2Spain, c/Dr. Aiguader, 80, 08003, |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion -- Reward |
| Session: |
421. Reward: Alcohol, Cannaniboids, and Morphine Poster |
| Presentation Time: | Monday, November 14, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # KK21 |
| Keywords: | CPP, microdialysis, dopamine, nucleus accumbens |
Cannabis and ecstasy (MDMA) are two of the most widely used recreational drugs often taken in combination by drug users. The aim of the present study was to investigate whether subthreshold doses of MDMA and delta9-tetrahydrocannabinol (THC) produced synergistic rewarding effects in mice. A conditioned place preference paradigm (CPP) was used to assess the rewarding properties of MDMA (0, 3, and 10 mg/kg, i.p.) alone and in combination with THC (0 and 0.3 mg/kg, i.p.). In addition, in vivo microdialysis in freely moving mice was performed in order to evaluate changes in extracellular dopamine levels in the nucleus accumbens following single or combined administration of MDMA (0 and 3 mg/kg) and THC (0 and 0.3 mg/kg). MDMA at the dose of 10 mg/kg produced a significant CPP, while neither MDMA (3 mg/kg) nor THC (0.3 m/kg) produced this effect. The combination of ineffective doses of MDMA and THC induced a significant CPP compared to each drug given by itself. However, THC did not potentiate the CPP produced by MDMA at the dose of 10 mg/kg. The extracellular levels of dopamine in the nucleus accumbens were increased by THC (0.3 mg/kg: 91%), and a slight enhancement was also observed following MDMA (3 mg/kg: 28%) with respect to baseline levels. However, when MDMA (3 mg/kg) was administered 15 min prior to THC (0.3 mg/kg), the increase observed in dopamine levels was similar to MDMA administration alone (34%). These results suggest that subthreshold doses of MDMA and THC have synergistic rewarding effects, but that the effectiveness of MDMA is not increased by a low dose of THC.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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