Neuroscience 2001 Abstract
| Presentation Number: | 463.4 |
|---|---|
| Abstract Title: | Tacking of pathology in PDAPP mice by MRI: A two-year longitudinal study. |
| Authors: |
Zhang, L.*1
; Kim, K. R-.1
; Bales, K.2
; Paul, S. M.2
; Benveniste, H.1,3
1Department of Anesthesiology, SUNY-SB, Stony Brook, NY 2Lilly Research Laboratories, Indianapolis, IN 3Medical Department, Brookhaven National Laboratories, Upton, NY |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimers Disease: Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Genetic Models |
| Session: |
463. Neurodegenerative disorders: Alzheimer's disease--pathology and imaging Slide |
| Presentation Time: | Tuesday, November 13, 2001 8:45 AM-9:00 AM |
| Location: | Room 30C |
| Keywords: | ALZHEIMER, MODEL, MRI, IMAGING |
Transgenic mouse models of Alzheimer’s disease are produced to understand the role of particular genes and to have available animal models, which mimic the clinical condition in order to test therapeutic interventions. Thus, there is a growing need for non-invasive tracking of pathology in mice at high spatial resolutions, afforded by high-resolution MRI (microMRI). - In this study we used microMRI to follow structural changes over 2 years in brains of transgenic mice overexpressing V717F APP (PDAPP mice).
Homozygous (n=11), heterozygous (n=8) PDAPP female mice and wildtype controls (n=7) initially 3-6 months of age were used for the study. The mice were imaged every three months for 22 months. All imaging was performed on a 7.1 T magnet using a 3D diffusion-weighted sequence and a spatial resolution of 58 µm x 58 µm x 469 µm. Quantitative analysis of was performed using NIH image.
The most striking structural difference between homozygous PDAPP mice and wildtype mice was the magnitude of lateral and 3rd ventricle volumes. Interestingly, in heterozygous PDAPP mice ventricle volumes enlarged spontaneously at 10-11 months of age. Additional abnormalities will be reported.
Homozygous (n=11), heterozygous (n=8) PDAPP female mice and wildtype controls (n=7) initially 3-6 months of age were used for the study. The mice were imaged every three months for 22 months. All imaging was performed on a 7.1 T magnet using a 3D diffusion-weighted sequence and a spatial resolution of 58 µm x 58 µm x 469 µm. Quantitative analysis of was performed using NIH image.
The most striking structural difference between homozygous PDAPP mice and wildtype mice was the magnitude of lateral and 3rd ventricle volumes. Interestingly, in heterozygous PDAPP mice ventricle volumes enlarged spontaneously at 10-11 months of age. Additional abnormalities will be reported.
Supported by Alzheimer's Association and AFAR
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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