Neuroscience 2001 Abstract
| Presentation Number: | 458.2 |
|---|---|
| Abstract Title: | Correlation of Odorant Structures with the Activity Patternsin the Rat Olfactory Bulb by Functional MRI. |
| Authors: |
Xu, F.*1
; Kida, I.1
; Hyder, F.1
; Shulman, R. G.2
1Dept Radiology, Yale Univ Med Sch, New Haven, CT 2Mol. Biophysics and Biochem., Yale Univ Med Sch, New Haven, CT |
| Primary Theme and Topics |
Sensory Systems - Chemical Senses -- Olfaction: CNS pathways and physiology |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Learning & memory: Physiology and imaging |
| Session: |
458. Chemical senses: olfactory system--odor coding Slide |
| Presentation Time: | Tuesday, November 13, 2001 8:15 AM-8:30 AM |
| Location: | Room 7B |
| Keywords: | OLFACTION, ODOR, IMAGING, BRAIN |
It is believed that the olfactory bulb (OB) codes the olfactory information from the periphery into a spatial activity pattern in the glomerular layer. Here we used high-resolution fMRI to examine how the structural features of odorants are represented spatially in the entire rat OB. The whole OB mapping results showed that the areas activated by the three structurally related odorants, iso-amyl acetate, ethyl acetate, and benzyl acetate distributed broadly across the entire OB. Many of the activated regions are shared by all three odorants. The patterns are more similar between the two aliphatic acetates than between the aliphatic and aromatic acetates. Statistical analysis showed that the similarity between the patterns of iso-amyl acetate in different exposures is significantly higher than between the patterns of iso-amyl acetate and ethyl acetate. One major cluster, covering nearly 60 glomeruli (thresholded at p < 0.01) at the latero-ventral region in the anterior end of the OB, was activated by the aliphatic acetates more strongly, whereas a cluster with ~30 glomeruli located at the antero-dorsal region was only activated by benzyl acetate. Detailed analysis showed that even within the clusters activated somewhat by all three odorants, the intensities of the patterns were different. These results showed that the glomeruli are arranged as clusters in the OB to recognize specific chemical moiety, and for given odorant pairs, the similarity between activity patterns parallels the similarity between the odorant structures.
Supported by Supported by NIH grants, DC-003710 (RGS), NS-37203 (FH) and NSF grant, DBI-9730892 (FH).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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