Neuroscience 2005 Abstract
| Presentation Number: | 409.11 |
|---|---|
| Abstract Title: | Apolipoprotein E and brain development in healthy children and adolescents. |
| Authors: |
Taylor, K. N.*1
; Rose, A. B.1
; Ordaz, S. J.1
; Clasen, L. S.1
; Blumenthal, J. A.1
; Lenroot, R.1
; Wallace, G. L.1
; Myers, A. J.2
; Hardy, J.2
; Giedd, J. N.1
1Child Psychiatry Branch, Natl Inst. Mental Hlth, Bethesda, MD 2MD, 10 Ctr Dr. MSC 1367, 20892, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Genetic variation and individual differences |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Anatomy |
| Session: |
409. Genetic Variation and Individual Differences Poster |
| Presentation Time: | Monday, November 14, 2005 10:00 AM-11:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # DD29 |
| Keywords: | GENETICS, IMAGING, MORPHOMETRY |
The apoliprotein E (ApoE) e4 allele has been labeled a risk factor for late onset Alzheimer’s disease and has been associated with a greater rate of brain atrophy in healthy older adults (E.M. Reiman, A. Uecker, R.J. Caselli, S. Lewis, D. Bandy, M.J. de Leon, S. De Santi, A. Convit, D. Osborne, A. Weaver, S.N. Thibodeau, Ann Neurol., 44, 288-291) as well as abnormally low rates of glucose metabolism in younger adults bearing one e4 allele (E.M. Reiman, K. Chen, G.E. Alexander, R.J. Caselli, D. Bandy, D. Osborne, A.M. Saunders, J. Hardy, Proc Natl Acad Sci USA, 101, 284-289). To date, no studies have addressed the effects of ApoE on brain development in a pediatric population. The longitudinal nature of our study allows us to track the correlation of ApoE genotype with brain volumes at different ages, possibly elucidating the effects of this gene over time. 292 healthy subjects (age range 6 to 22 years) were recruited for participation in an ongoing longitudinal magnetic resonance imaging (MRI) study at the Child Psychiatry Branch of the National Institute of Mental Health. All subjects were scanned on the same GE 1.5 T Signa scanner using the same 3D SPGR imaging protocol. Pyrosequencing technology was used to determine subjects’ ApoE genotypes, after which subjects were grouped accordingly: those with at least one e4 allele (e4), and those with no e4 alleles (non-e4). Mixed model regression analysis revealed trends suggesting reduced overall grey matter, frontal grey matter, and temporal grey matter volumes at the average age (12.95 years) in the e4 group (p=0.07, 0.088, and 0.11, respectively). These findings may indicate a pattern of early development by ApoE genotype similar to changes in healthy older adults, perhaps suggesting an early effect of the ApoE e4 allele on brain morphometry.
Supported by National Institute of Mental Health Intramural funding
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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