Neuroscience 2002 Abstract
| Presentation Number: | 453.12 |
|---|---|
| Abstract Title: | SPINAL NOREPINEPRHINE DEPLETION ATTENUATES CANNABINOID ANTINOCICEPTION. |
| Authors: |
Gutierrez, T.*1
; Neeley, M. H.1
; Freeman, K. G.2
; Edwards, G. L.2
; Hohmann, A. G.1
1Psychology, Univ Georgia, Athens, GA 2Physiology/Pharmacology, Univ Georgia, Athens, GA |
| Primary Theme and Topics |
Sensory Systems - Pain Modulation -- Opiods, cannabinoids and other peptides and receptors |
| Secondary Theme and Topics | Sensory Systems<br />- Pain Modulation<br />-- Brainstem pathways and descending control |
| Session: |
453. Pharmacology: cannabinoids Poster |
| Presentation Time: | Tuesday, November 5, 2002 11:00 AM-12:00 PM |
| Location: | Hall A2-B3 F-41 |
| Keywords: | spinal , spinal cord, descending pathway, monoamine |
The antinociceptive effects of the cannabinoid agonist delta-9-tetrahydrocannabinol are inhibited by spinal administration of an α²-noradrenergic receptor antagonist (Lichtman & Martin, Brain Res. 559: 309-314, 1991). In the present study, the antinociceptive effects of the cannabinoid agonist WIN55,212-2 were assessed in rats depleted of spinal norepinephrine. The neurotoxin 6-hydroxydopamine (6-OHDA; 20 µg) was administered intrathecally (i.t.) to deplete spinal norepinephrine. Sham-operated rats were treated identically but received the vehicle (10 µl i.t.). After establishing stable baseline responses to thermal stimulation of the tail on the test day, WIN55,212-2 (5 or 10 mg/kg) or vehicle was administered and post-injection tail-flick latencies were recorded. The antinociceptive effects of the cannabinoid agonist were attenuated in rats whose norepinephrine levels were depleted by i.t. administration of 6-OHDA. High performance liquid chromatography was used to quantify monoamine levels in lesioned and sham-operated rats. Treatment 6-OHDA depleted norepinephrine in the lumbar spinal cord by 100% without affecting levels of dopamine or serotonin. These data suggest that cannabinoids modulate descending noradrenergic systems to produce antinociception (Support: DA14265).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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