Neuroscience 2001 Abstract
| Presentation Number: | 430.20 |
|---|---|
| Abstract Title: | SPARED FUNCTION IN THE UNILATERAL 6-OHDA LESIONED RAT BY PRE-SURGICAL FORCED USE OF THE IMPAIRED FORELIMB: POSSIBLE ROLE FOR TROPHIC FACTORS. |
| Authors: |
Cohen, A. D.*1
; Tillerson, J. L.1
; Moroz, I.2
; Zigmond, M. J.3
; Smith , A.3
; Austin, M.3
; Stewart, J.2
; Schallert, T.1,4
1Institute for Neurosci, Univ of Texas, Austin, TX 2Concordia University, Montreal, Canada 3Univ of Pittsburgh, Pittsburgh, PA 4Univ of Michigan, Ann Arbor, MI |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Parkinsons DIsease: Models |
| Session: |
430. Neurodegenerative disorders: Parkinson's disease--neurotoxins Poster |
| Presentation Time: | Monday, November 12, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall WW-67 |
| Keywords: | PARKINSON, GROWTH FACTOR, MOVEMENT, PLASTICITY |
Physical activity promotes expression of neurotrophic factors, as well as neurogenesis in adult rats. Exogenous neurotrophic factors protect against nigrostriatal dopamine (DA) cell loss and functional impairment in rats. We have recently shown that exclusive use of the impaired forelimb by immobilizing the non-impaired forelimb during the first 7 days after partial, unilateral 6-OHDA lesions results in long-term protection of striatal DA tissue content and limb use. Additionally, we have shown partial damage to DA neurons yields an increase in expression of the neurotrophic and neuroprotective factor, FGF-2, in SN and VTA (Moroz & Stewart, SFN Abst. 2000). Here, we examined the effects of forced limb use for 7 days before infusion of 6-OHDA. Compared to control animals, the animals forced to use the to-be impaired limb showed no behavioral asymmetries in a battery of sensorimotor tests. In addition, forcing SHAM-operated animals to use one forelimb exclusively for 7 days caused an increase in the number of FGF-2 positive cells in SN and VTA. The effect of forced exercise on growth factors, such as GDNF and/or BDNF, are currently being examined. These data suggest that forced forelimb use before insult to nigrostriatal neurons provides neuroprotective effects that may be associated with behavior-assisted upregulation of neurotrophic factors.
Supported by NINDS grants NS23979 and NS19608, and CIHR Canada
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
