Neuroscience 2004 Abstract
| Presentation Number: | 375.4 |
|---|---|
| Abstract Title: | MRI-predictors of incident Alzheimer’s disease: A longitudinal study. |
| Authors: |
Stoub, T. R.*1
; Leurgans, S.1
; Bennett, D. A.1,2
; Fleischman, D.1,2
; Turner, D.3
; deToledo-Morrell, L.1,2
1Neurological Sci, Rush Univ, Chicago, IL 2Rush Alzheimer’s Dis. Ctr, Rush Univ, Chicago, IL 3Diagnos. Radiology & Nuclear Med., Rush Univ, Chicago, IL |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: Cognitive function |
| Session: |
375. Imaging Pathology in Neurodegenerative Disease Slide |
| Presentation Time: | Monday, October 25, 2004 8:45 AM-9:00 AM |
| Location: | San Diego Convention Center - Room 25A |
| Keywords: | AGING, HIPPOCAMPUS, ENTORHINAL CORTEX, BRAIN IMAGING |
The entorhinal cortex (EC) and hippocampal formation (HF) are pathologically affected very early in Alzheimer’s disease (AD). Therefore, the in vivo quantitation of changes in these regions is of great interest for identifying those at risk for developing AD. In the present study we used proportional odds models to assess the relationship between EC and HF size and risk of incident AD among 58 non-demented elderly people. All participants were followed with yearly clinical evaluations and high resolution MRI scans for up to 6 years. 23/58 people received a diagnosis of amnestic mild cognitive impairment (MCI) during the baseline evaluation and 35/58 had no cognitive impairment (NCI). EC and HF volumes were derived from 1.6 mm gapless T1 weighted coronal images reformatted to be perpendicular to the long axis of the HF. The Analyze software was used for volumetric determinations and the coregistration of sequential scans. Of the 58 non-demented subjects, 14 developed AD during the follow-up period. Results from the proportional odds analyses showed that initial diagnosis (MCI or NCI) was a significant predictor of incident AD [χ2(1)=16.569, p<0.0001]. Baseline EC volume and its slope of decline independently predicted incident AD; their addition to initial diagnosis and to initial diagnosis + HF volume (baseline and slope) significantly improved the model [χ2(2)=10.031, p=0.0066 and χ2(2)=7.514, p=0.028 respectively]. However, HF volume (baseline and slope of decline) was not an independent predictor of incident AD. Adding HF volume to initial diagnosis or to initial diagnosis + EC volume did not improve the model based on initial diagnosis alone. These results demonstrate that in non-demented individuals EC, but not HF atrophy is associated with risk of AD.
Supported by P01 AG09466, P30 AG10161 & R01 AG17917
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
