Neuroscience 2001 Abstract
| Presentation Number: | 422.20 |
|---|---|
| Abstract Title: | Δ-9-THC interferes with the establishment of lithium- and amphetamine-induced place conditioning. |
| Authors: |
Sorge, R. E.*1
; Parker, L. A.1
1Dept of Psych, Wilfrid Laurier Univ, Waterloo, Canada |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion |
| Session: |
422. Motivation and emotion: reward and motivation I Poster |
| Presentation Time: | Monday, November 12, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall UU-48 |
| Keywords: | nausea, emesis, learning, addiction |
The potential of Δ-9-THC to interfere with place conditioning in rats was evaluated in three experiments. Experiment 1 was designed to evaluate the potential of a low dose of THC (0.5 mg/kg, ip) to interfere with the establishment and/or the expression of lithium-induced place avoidance. Since lithium produces nausea, this experiment aimed to evaluate the potential of THC to interfere with unconditioned or conditioned nausea in rats. As measured by resistance to extinction across test trial cycles, pretreatment with THC interfered with (but did not eliminate) lithium-induced place aversion learning without producing place conditioning on its own. In Experiment 2, THC eliminated a weaker lithium-induced place aversion produced by a single conditioning trial cycle. Experiment 3 evaluated whether the interference with place aversion learning was the result of interference with nausea or interference with learning. Rats were pretreated with THC prior to place preference conditioning with amphetamine. Indeed, THC also interfered with amphetamine place preference learning. Our results suggest a very low dose of Δ-9-THC (0.5 mg/kg, ip) interferes with learning in the place preference and/or place aversion paradigm.
Supported by Natural Sciences and Engineering Research Council of Canada
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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