Neuroscience 2000 Abstract
| Presentation Number: | 400.11 |
|---|---|
| Abstract Title: | Dose-related effects of Δ<SUP>9</SUP>-tetrahydrocannabinol on local cerebral glucose utilization. |
| Authors: |
Freedland, C. S.*1
; Whitlow, C. T.1
; Williams, L. A.1
; Miller, M. D.1
; Porrino, L. J.1
1Physiology & Pharmacology, Wake Forest Univ Sch of Med, Winston-Salem, NC |
| Primary Theme and Topics |
D. Neurotransmitters, Modulators, Transporters, and Receptors - 54. Cannabinoids |
| Secondary Theme and Topics | H. Other Systems of the CNS<br />- 101. Brain metabolism and blood flow |
| Session: |
400. Pain modulation: pharmacology Slide |
| Presentation Time: | Tuesday, November 7, 2000 10:30 AM-10:45 AM |
| Location: | Room 283 |
| Keywords: | cannabinoids, autoradiography, metabolism, mapping |
Recent reports have shown that Δ9-tetrahydrocannabinol (THC) stimulates locomotor activity at low doses (≤2.0 mg/kg), while higher doses (>2.0 mg/kg) produce decreases in spontaneous activity. Using quantitative [14C]2-deoxyglucose (2-DG) autoradiography we have systematically studied the effects of acute Δ9-tetrahydrocannabinol in these dose ranges on rates of local cerebral glucose utilization. The present series of experiments was designed to determine if THC-mediated changes in cerebral metabolism followed a clear dose-response relationship. Adult male Sprague-Dawley rats were treated with either vehicle or THC (0.25, 1.0, or 2.5 mg/kg, i.p.) and the 2-DG procedure was initiated 15 min following exposure. Administration of 2.5 mg/kg THC produced significant decreases in cerebral metabolism in most brain regions studied. In contrast, administration of the two lower doses (0.25, 1.0 mg/kg) of THC produced more restricted effects on metabolism. Significant decreases in metabolism were limited to anterior cingulate, anterior accumbens, caudate, and basolateral amygdala. These data contrast with previous reports which described a biphasic metabolic response to THC in this dose range. These findings indicate that the effects of THC on cerebral metabolism are dose-related and that there are regional differences in the metabolic response to acute cannabinoid exposure. Further, these data demonstrate that changes in cerebral metabolism do not parallel the changes in spontaneous activity described in the literature.
Supported by DA05940 (CSF) and DA06634 (LJP)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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