Neuroscience 2000 Abstract
| Presentation Number: | 397.6 |
|---|---|
| Abstract Title: | Behavioral consequences of vaccination with human β-amyloid in mutant APP + PS1 transgenic mice. |
| Authors: |
Arendash, G.*1
; Hatcher, J.1
; Canals, K.2
; Diamond, D. M.2
; Gottschall, P.3
; Gordon, M.3
; Morgan, D.3
1Depts. of Biology, University of South Florida, Tampa, FL 2Psychology, University of South Florida, Tampa, FL 3and Pharmacology, University of South Florida, Tampa, FL |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 126. Degenerative disease: Alzheimer's-beta amyloid |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 128. Degenerative disease: Alzheimer's-cognitive function |
| Session: |
397. Degenerative disease: Alzheimer's--beta amyloid: animal models IV Slide |
| Presentation Time: | Tuesday, November 7, 2000 9:15 AM-9:30 AM |
| Location: | Room 268 |
| Keywords: | Cognitive Protection, Innoculation, Beta-Amyloid, Alzheimer's Disease |
Recently, vaccination of the PDAPP transgenic mouse with human beta-amyloid (Aβ) peptide was found to prevent or decrease Aβ deposition in the brain (Schenk et al., Nature 400:173, 1999). The present study investigated the behavioral consequences Aβ vaccination in doubly transgenic APP+PS1 mic. These mice are cognitively normal through 6-8 months of age but impaired by 16-17 months (see abstract by A. Campbell et al.), which parallels their progressive increase in brain Aβ deposition. At 8 months of age, doubly transgenic mice (Tg+) and non-transgenic (Tg-) controls began receiving months vaccinations with human Aβ1-42 or KLH control vaccinations. Behavioral testing of Tg+ and Tg- mice at 12 months of age (when blood Aβ antibody titers should be about 1:10,000) revealed no deleterious effects of Aβ vaccination on learning/working memory in the radial arm water maze (RAWM) task. Behavioral results from a follow-up RAWM test at 16 months of age will be presented. Also, human Aβ1-42 vaccination of 14 months old Tg+ mice from a different genetic background (bub strain) had no deleterious effects on a variety of sensorimotor and cognitive tasks; this, despite substantive blood Aβ antibody titers. Our results indicate that Aβ vaccinations in Tg+ mice bearing Aβ deposits do not impair their cognitive performance, thus providing an opportunity for cognitive protection during aging.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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