Neuroscience 2002 Abstract
| Presentation Number: | 404.2 |
|---|---|
| Abstract Title: | USEFULNESS OF MRI FOR DISTINGUISHING VASOGENIC AND CYTOTOXIC EDEMA AFTER HEAD INJURY. |
| Authors: |
Dunn, J. F.*1
; Dwyer, B. E.2
; Lu, S. Y-.2
; Nishimura, R. N.3
1NMR Research Laboratory, Dartmouth-Hitchcock Med Ctr, Lebanon, NH 2Research Service (151), VA Med Ctr, White River Junction, VT 3Department of Neurology, VA Med Ctr, Sepulveda, CA |
| Primary Theme and Topics |
Techniques in Neuroscience - Staining, tracing and imaging techniques |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Trauma<br />-- Brain |
| Session: |
404. Staining, tracing, and imaging techniques IV Poster |
| Presentation Time: | Monday, November 4, 2002 2:00 PM-3:00 PM |
| Location: | Hall A2-B3 Z-38 |
| Keywords: |
Preliminary studies suggest that MRI may be useful for distinguishing between vasogenic edema (open BBB edema) and cytotoxic or cellular edema (closed BBB edema). Cold injury-induced brain trauma (CIBT) is the classic small-animal model of vasogenic cerebral edema. Rats were anesthetized and maintained at 37oC. The skull was exposed, and a cooled brass probe was placed in direct contact with the skull, over the right hemisphere, for 2 minutes. Twenty-four hours later MRI was performed. Images were collected on a 7T horizontal bore MR system with 220mT/m actively shielded gradients (TR/TE = 8/0.05 s, pixel resolution = 115x230x1000µm. The T2 weighted image and T2 map clearly delineated the borders of the infarct. The contrast in both images was maximal at the base of the infarct. BBB integrity was also assessed 24-hours after CIBT from gadolinium (Gd)-enhanced, T1-weighted images obtained 30 minutes after a tail-vein injection of Gd-DTPA. It was noteworthy that BBB breakdown was most extensive along the top of the infarct. It remains to be confirmed whether enhanced T2 at the base of the infarct reflects increased water due to cytotoxic edema versus water trapped in tissue after the BBB is reformed. If cytotoxic edema is confirmed the use of combined T2 imaging and Gd-enhanced T1 imaging may provide a useful method to quantitate and monitor vasogenic and cytotoxic edema following brain injury.
Supported by The Office of Research and Development, Medical Research Service, Department of Veterans Affairs
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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