Neuroscience 2001 Abstract
| Presentation Number: | 400.5 |
|---|---|
| Abstract Title: | In-vivo visualization of endolymphatic hydrops: Evaluation of experimental endolymphatic hydrops in guinea pigs with 4.7 T MRI-scanning. |
| Authors: |
Chen, Z.*1
; Pyykk・ I"2
; Bretlau, T.3
; Klason, T.1
; Zou, J.2
; Bjelke, B.1
1Clinical Neuroscience, MR Research Center, Karolinska Inst, Stockholm, Sweden 2Otolaryngology, Karolinska Inst, Stockholm, Sweden 3Otolaryngology Head & Neck Surgery, Rigshopitalet, Copenhagen, Denmark |
| Primary Theme and Topics |
Sensory Systems - Auditory -- Peripheral |
| Secondary Theme and Topics | Sensory Systems<br />- Auditory<br />-- Central Anatomy |
| Session: |
400. Auditory: peripheral I Poster |
| Presentation Time: | Monday, November 12, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall DD-4 |
| Keywords: | Animal model, Magnetic, Uptake, Cochlea |
In order to find out whether it is possible to detect EH with a 4.7 T MRI device, five guinea pigs were used for evaluating the dynamic change of gadolinium uptake in normal cochlea n=15 and experimental induced EH. Two kinds of operation were used to obtain an EH-endolymphatic sac (ES) intact group (n=6) and ES -damaged group (n=9). D-aldosterone (1 mg/kg) was given to 6 animals in the ES -damaged group, injected 8-9 days after ES surgery. MRI was performed and hearing was tested by ECoG in the ES- damaged group. It was found that as early as 5 days after ES surgery, EH started in all animals as verified by MRI scannings and histology. Serious damage to the inner ear barrier was detected with MRI in one advanced stage animal, which received D-aldosterone injection with a 60 dB hearing loss. Three areas of the cochlea were measured and area factor with scala vestibuli or scala tympani as reference were used for quantitative evaluation of EH. For EH to be defined as being present 87.5 % (7/8) of all the area factors must to be abnormal. The angle between Reissner's membrane and the basilar membrane was measured by MRI and for EH to be defined as being present 75 % (3/4) must be abnormal. Our results indicate that by using functional morphology MRI with gadolinium, quantitative in-vivo visualization of EH is possible.
Supported by Konung Gustaf V:s och Drottning Viktorias Stiftelse, Karolinska Institutet Foundations
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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