Neuroscience 2003 Abstract
| Presentation Number: | 324.16 |
|---|---|
| Abstract Title: | Effect of <I>in utero</I> exposure to δ-9-THC on the behavior of C57BL/6J mice. |
| Authors: |
Fetsko, L. A.*1
; Colwill, R. M.1
1Dept. Psych, Brown Univ, Providence, RI |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Executive function |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Addiction and Drugs of Abuse<br />-- Opioids and others |
| Session: |
324. Developmental Cognition & Disorders Poster |
| Presentation Time: | Sunday, November 9, 2003 4:00 PM-5:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # VV59 |
| Keywords: | CANNABINOIDS, DRUG ABUSE, FACILITATION, LOCOMOTOR ACTIVITY |
Longitudinal studies of children whose mothers smoked marijuana during their pregnancy suggest a relationship between prenatal exposure to marijuana and deficits in various components of executive function. We have developed a mouse model to examine the effects of in utero exposure to Δ-9-tetrahydrocannabinol (THC) on executive function processes. In the series of experiments reported here, we trained mice on a facilitation task in which one stimulus (the facilitator) provides information about the relationship between another stimulus (the target) and food. In Experiment 1, we found no difference in the rate of acquisition of the facilitation task in mice exposed in utero to vehicle, 5 mg/kg THC, or 10 mg/kg THC. In Experiment 2, we found no differential effect of an acute dose of 1 mg/kg THC on performance on the facilitation trials in mice exposed in utero to vehicle, 5 mg/kg THC, or 10 mg/kg THC. However, the challenge dose did increase responding in the intervals between trials (ITIs) compared to a vehicle injection in all three groups of mice. Experiment 3 explicitly examined this effect of the drug on locomotor activity. We found a dose-dependent decrease in locomotor activity, with animals exposed to THC in utero showing greater sensitivity to increasing doses of THC. The implications of these results for understanding the action of in utero THC exposure and acute THC challenges on cognition and behavior are discussed.
Supported by NIDA R21DA14202
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Copyright © 2003-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
