Neuroscience 2003 Abstract
| Presentation Number: | 324.3 |
|---|---|
| Abstract Title: | Damage to perirhinal and parahippocampal TH/tf cortices in monkeys impairs performance on transverse patterning. |
| Authors: |
Alvarado, M. C.*1
; Bachevalier, J.1
1Dept. Neurobiol & Anat., UT-Houston Hlth. Sci. Ctr, Houston, TX |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Session: |
324. Developmental Cognition & Disorders Poster |
| Presentation Time: | Sunday, November 9, 2003 3:00 PM-4:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # VV59 |
| Keywords: | Configural, relational, macaque |
Neurotoxic damage to the hippocampal formation impairs performance on the transverse patterning task (Alvarado et al., 1998, SFN ABST #366.4). However, recent data indicate that surrounding medial temporal cortical areas also play important roles in object memory, suggesting that they may be critical for performance of this task. Thus, we tested monkeys with aspiration lesions of either the perirhinal cortex (PRh) or parahippocampal areas TH/TF (TH/TF), and normal controls on two sets of transverse patterning problems. The animals were trained in 3 successive phases as follows: Phase 1, A+ B-, Phase 2, A+ B-, B+ C-, Phase 3, A+ B-, B+ C-, C+ A-. Note that only in Phase 3 is a configural/relational solution required for accurate performance. Trials to criterion for Phases 1, 2 and 3 respectively were: Controls: 31.7, 75.0, 522.5. TH/TF: 35.0, 85, 923.0. PRh: 33.3, 83.0, 925.0. Both experimental groups differed from Controls in Phase 3 (p's < 0.05) but not in Phases 1 and 2. Only one monkey in Group TH/TF completed Phase 3 (avg: 825 trials), a second solved one set (885 trials) and one monkey in Group PRh also solve a single problem set (515 trials). Performance patterns demonstrated that the operated animals were using elemental strategies to perform Phase 3, which was confirmed when a transfer task was given: A+ B-, B+ C-, C+ X-. They learned those discriminations rapidly (TH/TF: 131.3 trials; PRh: 205 trials), indicating that the nature of their deficit was not simply perceptual or an inability to learn about objects. The present data support the suggestion that some aspects of configural learning can be supported by medial temporal cortex (e.g., O'Reilly & Rudy, Hippocampus (10), 2000). What remains to be determined is how, or if, their contribution to performance of this task differs from that of the hippocampus.
Supported by MH-58846 to JB
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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