Neuroscience 2001 Abstract
| Presentation Number: | 397.17 |
|---|---|
| Abstract Title: | FUNCTIONAL MAGNETIC RESONANCE IMAGING OF THE RETINA. |
| Authors: |
Duong, T. Q.*1
; Ngan, S. C.1
; Kim, D. S.1
; Ugurbil, K.1
; Kim, S. G.1
1Ctr Magnetic Reson Res, Univ Minnesota Sch Med, Minneapolis, MN |
| Primary Theme and Topics |
Sensory Systems - Vision -- Retina and photoreceptors |
| Secondary Theme and Topics | Sensory Systems<br />- Vision<br />-- Striate visual cortex: Functional organization and circuitry |
| Session: |
397. Vision: retina and photoreceptors--ganglion cells Poster |
| Presentation Time: | Monday, November 12, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall Y-3 |
| Keywords: | Retina, Imaging, Blood flow, Metabolism |
The ability to image retinal functions non-invasively and in three dimensions can have numerous potential applications. We explored the feasibility of mapping the retina's responses to visual stimuli in anesthetized cats by using blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI). Functional maps obtained with a spatial resolution of 470x470x1000 mm3 showed increased activity along the retina following visual stimulation (drifting gratings). The BOLD fMRI signal increases ranged from 1.0-2.5% relative to basal (dark) conditions. Hemi-field stimulation studies demonstrated that stimuli presented to the upper half of the visual field stimulated the lower part of the retina, while stimuli presented to the lower half of the visual field stimulated the upper part of the retina, as expected. Multi-slice functional images of the retina were reconstructed and flattened onto a two-dimensional surface. No statistically significant activation was observed around the blind spot. To the best of our knowledge, this is the first fMRI study of the retina, demonstrating its feasibility. This modality should provide a unique platform to image the retinal functions in a non-invasive and serial manner.
Supported by NIH (RR08079, NS10930, NS38295, MH57180), Keck Fdn.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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