Neuroscience 2004 Abstract
| Presentation Number: | 330.14 |
|---|---|
| Abstract Title: | Head direction cell ensemble representations are more coherent than CA1 place cell representations in a cue-conflict environment. |
| Authors: |
Yoganarasimha, D.*1
; Lee, I.1
; Knierim, J. J.1
1Neurobiology and Anat., Univ. of Texas Med. Sch., Houston, TX |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Cognitive learning and memory systems |
| Session: |
330. Mapping and Remapping Poster |
| Presentation Time: | Sunday, October 24, 2004 2:00 PM-3:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # NN10 |
| Keywords: | SPATIAL ORIENTATION, ATTRACTOR, MULTIELECTRODE, THALAMUS |
Hippocampal place cells are selectively active when a rat occupies restricted locations in an environment. Head direction (HD) cells fire selectively when the rat's head is pointed in a particular direction in allocentric space. Both place cells and HD cells have been modeled as attractor neural networks. If the intrinsic connections of an attractor network are strong compared to the external inputs, the network should tend to maintain internal coherency of its representation when the input patterns are altered. Previous studies have shown that the CA3 network is more coherent than the CA1 network when the distal landmarks in a familiar environment are rotated relative to the salient local cues on the behavioral track (Lee et al., SFN Abstracts, 2003). To test whether the HD cell system remained coherent under these conditions, ensembles of 1-33 hippocampal CA1 place cells & 2-9 HD cells from the anterior dorsal nucleus of the thalamus were recorded simultaneously in 6 rats during standard (familiar) and cue-mismatch sessions, in which the local cues were rotated counterclockwise (CCW) and the distal cues clockwise (CW) (45°, 90°, 135°, or 180° mismatch between local & distal cues). The CA1 place cell ensemble showed evidence of a split representation in 53% (46/86) of the mismatch sessions, as some place fields rotated CW and other fields rotated CCW. In contrast, HD cells never exhibited a split representation, as every cell in the ensemble always rotated their tuning curves in the same direction either CW (93%; 80/86 sessions) or CCW (7%; 6/86 sessions). These results are consistent with attractor network models of HD cells, as these cells are more strongly coherent in their response properties in comparison to CA1 place cells.
Supported by R01 NS39456 and K02 MH63297
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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