Neuroscience 2004 Abstract
| Presentation Number: | 330.9 |
|---|---|
| Abstract Title: | Place representation in the deep layers of entorhinal cortex. |
| Authors: |
Sargolini, F.*1
; Molden, S.1
; Witter, M. P.1,2
; Moser, E. I.1
; Moser, M.1
1Dept Psychol, Norwegian Univ Sci & Tech, Trondheim, Norway 2Netherlands, NTNU, N-7491, |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Associative, nonassociative and skill learning & memory systems |
| Session: |
330. Mapping and Remapping Poster |
| Presentation Time: | Sunday, October 24, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # NN10 |
| Keywords: | parahippocampal system, place cells, multipeaked firing fields, rat |
The interaction between neocortex and hippocampus is essential for encoding, storage and retrieval of memory. Input from the neocortex reaches the hippocampus (HPC) mainly by way of superficial layers of the entorhinal cortex (EC). Putative excitatory cells in these layers have multipeaked multidirectional firing fields, collectively signalling the rat’s location as efficiently as downstream place cells in the HPC (Fyhn et al., SfN 2003). We asked whether spatial location is expressed similarly in deeper layers of the EC, which receive a dense innervation back from the HPC but only sparse input from superficial layers of the EC. Tetrodes were implanted in layers V and VI of the rat EC, and spatial modulation of firing was recorded from parallel-recorded cells while the rats chased food in square (A) and circular (B) enclosures, using an A-B-A design. Putative excitatory cells in layers V and VI had stable multipeaked and multidirectional place fields similar to those observed in layers II and III. Multipeaked firing fields were observed in both layers. The spatial information rate was comparable to that of superficial neurons, and the animal’s position could be predicted accurately from the collective activity of simultaneously recorded neurons in both superficial and deep layers. These results suggest that cell assemblies in EC span across all layers of the structure, either as a consequence of common inputs to deep and superficial neurons or as a reflection of intrinsic recurrent connections. The influence of hippocampal return projections on spatial firing in layers V and VI is currently being tested.
Supported by Norw. Res. Council Ctr. Excellence Grant
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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