Neuroscience 2003 Abstract
| Presentation Number: | 309.2 |
|---|---|
| Abstract Title: | Presence of collateral circulation after local cerebral ischemia in rat does not affect the accumulation of brain tissue sodium, [Na<sup>+</sup>], measured by sodium magnetic resonance imaging. |
| Authors: |
Yanovski, B.*1
; Kharlamov, A.1
; Kim, D. K.2
; LaVerde, G. C.3
; Boada, F. E.3
; Jones, S. C.1
1Anesthesiol., Allegheny Gen. Hosp, Pittsburgh, PA 2Neurosurgery, Allegheny Gen. Hosp, Pittsburgh, PA 3PA, Dept Anesthesiol, Res Lab, 15212-4772, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia -- Neuroprotection and tolerance |
| Session: |
309. Ischemia: Neuroprotection & Tolerance IV Poster |
| Presentation Time: | Sunday, November 9, 2003 2:00 PM-3:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # KK12 |
| Keywords: | STROKE, ISCHEMIA, SODIUM, MRI |
Brain [Na+] has been proposed to assess insult duration in evolving stroke (Wang et al, 2000 Stroke 31,1386). Stroke localization and the type of local blood supply may modify this relation. We hypothesized that the time course of [Na+] in cortical stroke (COR) where collateral circulation is present is different than in caudoputamen stroke (CP) where collateral circulation is absent. In Sprague-Dawley rats (~340 g) under isoflurane anesthesia focal ischemia was induced either by occlusion of the distal middle cerebral artery and both common carotid arteries or by insertion of an intraluminal suture through the internal carotid artery. 3D [Na+] data were obtained on a 3 T whole body scanner (GE MS) using a dual-tuned (23Na/1H), dual-quadrature birdcage RF coil. The infarct was located using ADC 1H images. [Na+] maps (twisted projection) were acquired every 5.3 min from which the [Na+] in % change from the average in normal cortex was measured vs. time after occlusion, Ta, in hours. The rate of [Na+] increase for COR and CP stroke was similar (1.15 + 0.14*Ta, r2=0.83; 1.06 + 0.15*Ta, r2=0.77, respectively). Thus, the [Na+] time course can describe the progression of stroke for cortical as well as for subcortical regions.
Supported by NIH NS 30839 and the Whitaker foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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