Neuroscience 2002 Abstract
| Presentation Number: | 382.11 |
|---|---|
| Abstract Title: | Hearing songs modulates activity in the HVc to RA projection of canaries: a manganese-enhanced MRI study. |
| Authors: |
Tindemans, I.*1
; Verhoye, M.1
; Balthazart, J.2
; Van der Linden, A.1
1Bio-Imaging Lab, Univ Antwerp (RUCA), Antwerp, Belgium 2Ctr Cell Mol Neurobiol, Univ Liege, Liege, Belgium |
| Primary Theme and Topics |
Cognition and Behavior - Neuroethology -- Comparative Anatomy and Brain Evolution |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Learning & memory: Physiology and imaging |
| Session: |
382. Neuroethology III Poster |
| Presentation Time: | Monday, November 4, 2002 3:00 PM-4:00 PM |
| Location: | Hall A2-B3 Q-2 |
| Keywords: | BRAIN IMAGING, SONGBIRD, AXONAL TRANSPORT, AUDITORY |
We demonstrated recently that nucleus Robustus Archistriatalis (RA) can be visualized in living canaries by Magnetic Resonance Imaging (MRI) following injection of manganese (Mn2+) in the High Vocal Center (HVc). Within a few hours Mn2+, a Ca2+ analogue, is taken up by HVc neurons. It is then transported to- and allows the visualization of RA. We investigated whether hearing conspecific songs, which affects electrical activity in HVc, can modulate the rate of RA labeling by Mn2+. Male canaries were chronically implanted with a cannula in HVc and serial MRI images were collected within the first 8 hours following Mn2+ injection on two occasions about 2-3 weeks apart in the same birds that were either exposed to conspecific songs or no songs throughout the MRI procedure. The Mn2+ uptake in RA as a function of time was fitted to a sigmoidal function providing estimates of the maximal intensity, shape of the curve and time to reach half of maximal intensity. Hearing songs induced a significant shift in the Mn2+ labeling resulting in significant differences in the curve shapes and in a significant increase in the amount of manganese taken up by RA after 6-7 hours. Topographical analysis of these responses also identified heterogeneity in the Mn2+ uptake by RA. The dorsal part of RA was in some birds affected more drastically by exposure to songs than its ventral part. These results demonstrate that Mn2+ enhanced MRI can potentially be used to assess the functional state of specific parts of the song system in a manner reminiscent of functional MRI but with higher anatomical resolution.
Supported by IWT, NS 35467, FWO G.0075.98N
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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