Neuroscience 2005 Abstract
| Presentation Number: | 333.11 |
|---|---|
| Abstract Title: | Rehabilitation improves motor system in a monkey model of chronic stroke. |
| Authors: |
Umemura, K.*1
; Takamatsu, H.2
; Hu, J.2
; Suzuki, Y.1
; Honjo, K.2
1Dept Pharmacol, Hamamatsu Univ. School of Medicine, Hamamatsu, Japan 2Japan, 1-20-1 Handayama, 431-3192, |
| Primary Theme and Topics |
Disorders of the Nervous System - Ischemia -- Human studies and animal models |
| Session: |
333. Hypoxia/Ischemia: Human Studies and Animal Models Poster |
| Presentation Time: | Sunday, November 13, 2005 3:00 PM-4:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # UU53 |
| Keywords: | ISCHEMIA, MRI, MCAO |
Rehabilitation is the most effective to improve neurological deficits in stroke patients. To investigate physiology of rehabilitation, we developed a monkey model of chronic stroke, and then examined the effects of rehabilitation. Male rhesus monkeys were subjected, and right middle cerebral artery was occluded for 4 hr with an embolization coil inserted from the femoral artery to the MCA using endovascular technique, and then the MCA occlusion was reopened by removing the coil. Infarct volume was determined using magnetic resonance imaging (MRI) at 7 and 90 days after the MCA occlusion and by pathohistological observation at 90 days after. Neurological deficits (consciousness level, motor system, muscle coordination, and sensory system) were observed 1, 3, 5, 7, 14, 21, 30, 60, and 90 days after the MCA occlusion. One group (n=6) treated with rehabilitation started from 7 days, and then continued until 90 days after the MCA occlusion, and the other (n=5) was treated without rehabilitation. In rehabilitation group, ipsilateral hand and limb were massaged and warmed for 30 min every day. Infarct volume was not different between tow groups at 7 and 90 days after the MCA occlusion by MRI evaluation. Rehabilitation significantly (P<0.05) improved neuronal deficits at 60 and 90 days after the MCA occlusion. Especially, in this study, the improvement by rehabilitation was observed in motor system. In this study, we established a chronic stroke model in monkeys for investigating brain functions, and furthermore, using this model, we could demonstrate the effectiveness of rehabilitation. In the next step, it will be required to investigate possible mechanisms of the improvement by rehabilitation.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
Copyright © 2005-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
