Neuroscience 2004 Abstract
| Presentation Number: | 319.18 |
|---|---|
| Abstract Title: | Longitudinal functional MRI of the development of cognitive control. |
| Authors: |
Durston, S.*1,2
; Davidson, M. C.1
; Tottenham, N.1
; Spicer, J.1
; Galvan, A.1
; Fossella, J. A.1
; Casey, B. J.1
1Sackler Inst. for Developmental Psychobiology, New York, NY 2Netherlands, 1300 York Avenue Box 140, 10021, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Cognitive development |
| Session: |
319. Cognitive Development Poster |
| Presentation Time: | Sunday, October 24, 2004 2:00 PM-3:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # FF7 |
| Keywords: | FRONTAL CORTEX, HUMAN COGNITION |
Cognitive control, defined as the ability to suppress irrelevant information and actions in favor of more relevant ones, has been shown to become more efficient with age. In the present study we explore the neural basis of this development in a longitudinal functional MRI study of children aged 7 to 12 years. Subjects, who had previously participated in a study using a go nogo paradigm, participated in a second fMRI session using a similar task. The subjects’ task was to press a button to a string of targets, but inhibit their response to a non-target (25 to 30% of trials). The average time interval between the sessions was 2 yrs and the average age at time 1 was 9 yrs (7.2-10.3), and 11 yrs (9.2-12.9) at time 2. Behaviorally, subjects became more accurate and faster in detecting the target (p < 0.001) from time 1 to time 2, but there were a similar number of false alarms. The imaging results showed that the average MR signal change between time 1 and 2 was no different in motor cortex for the comparison of go vs. nogo trials, but there was a decrease in activation of dorsolateral and posterior regions across time for the comparison of nogo versus go trails. The only region where MR signal change was found to increase was in left inferior frontal gyrus, a region previously shown to correlate with go/nogo performance. These results suggest that as children begin to reach adolescence, simple detection improves, but cognitive control is still developing. These behavioral changes are paralleled by an increase in recruitment of ventral prefrontal regions over subcortical (striatum) and other cortical regions consistent with less diffuse and more focal patterns of activity in regions that correlate with performance across development.
Supported by an NIMH R01 award to BJC and a stipend from the Netherlands Organisation for Scientific Research (NWO) to SD
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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