Neuroscience 2004 Abstract
| Presentation Number: | 319.15 |
|---|---|
| Abstract Title: | The NIH MRI study of normal brain development: Objective-1-behavioral analyses. |
| Authors: |
Botteron, K. N.*1
; Freund, L.3
1Psychiatry, Washington Univ Sch Med, St. Louis, MO 3MD, 660 S Euclid, 63110, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Cognitive development |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Staining, tracing and imaging techniques |
| Session: |
319. Cognitive Development Poster |
| Presentation Time: | Sunday, October 24, 2004 3:00 PM-4:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # FF7 |
| Keywords: | STRUCTURE, COGNITION, BRAIN IMAGING, DEVELOPMENT |
Objective: The NIH MRI Study of Normal Brain Development is being carried out by the “Brain Development Cooperative Group”. One primary goal of this multi-site study is to enroll a large sample of healthy infants, children and adolescents representative of the demographic characteristics of the U.S. population in order to establish healthy, regionally specific, brain development growth curves and to establish a MRI repository database of healthy subjects . The project is funded by NIH (NIMH, NICHD, NINDS, and NIDA). Methods: This report focuses on the recruitment, screening and cognitive/behavioral assessment related to Objective –1, which covers children from 4.5 to 18 years. Obj. 1 has completed the baseline subject enrollment, screening and scanning. Longitudinal follow up at 24 mo. intervals are planned. An epidemiological sampling frame was employed to recruit and screen. This strategy strives to minimizes biases present in samples of convenience. Targeted recruitment was based on zip code based U.S. census data specific to each of the 6 data collection sites. Introductory letters were mailed to families briefly describing the project. These were followed by phone calls initiating screening. Screening was completed in several stages prior to invitation for full day MRI and behavioral protocol. A 3-4 hour battery of assessments and tests were chosen for characterizing the population and investigating developmental brain - behavior correlates. Results: 456 subjects (ages 4.5-18 years) were recruited. 403 were successfully scanned. The sample is racially, ethnically and economically diverse generally reflecting U.S. population demographics. 28% of the subjects are racial or ethnic minorities. Characteristics of the screening and recruited populations will be presented. Conclusions: This large multisite MRI database will serve as a valuable resource to understanding healthy brain development.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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