Neuroscience 2004 Abstract
| Presentation Number: | 313.2 |
|---|---|
| Abstract Title: | Inhibition and task switching in patients with parkinsonian syndromes. |
| Authors: |
Rivaud-Pechoux, S.*1
; Vidailhet, M.2
; Brandel, J.
; Gaymard, B. M.1
1INSERM U.289, Paris, France 2France, Hopital la Salpetriere 47 Bd de l'hopital, 75651, |
| Primary Theme and Topics |
Motor Systems - Eye Movements -- Attention and visuomotor interations |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Anatomy |
| Session: |
313. Eye Movements: Attention and Cognition Poster |
| Presentation Time: | Sunday, October 24, 2004 2:00 PM-3:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # BB16 |
| Keywords: | executive functions, frontal cortex, antisaccade, human |
Task switching requires the ability to flexibly adjust a response to an external stimulus on a trial to trial basis. Previous clinical and brain imaging studies have shown that lateral (dorsolateral prefrontal cortex, DLPFC) and medial (anterior cingulate cortex, ACC; pre-supplementary motor area, pre-SMA) frontal areas could be involved in task switching. We have investigated switching abilities in 11 control subjects and in patients with parkinsonian syndromes in which the degenerative process affects mainly frontolateral areas: progressive supranuclear palsy (PSP), n=12, or frontomedial areas: Parkinson disease (PD) n=15, and cortico basal degeneration (CBD), n=8. Subjects performed 3 tasks: blocks of prosaccades (saccade towards a peripheral target, PS), blocks of antisaccades (saccade in the direction opposite to a peripheral stimulus, AS) and interleaved prosaccades and antisaccades (PAS) in which the colour of the fixation stimulus was the instruction to perform either a prosaccade (green) or an antisaccade (red). The error rate (misdirected saccades) was measured in each task. CBD and PD patients had an increased error rate in PAS task for both pro and antisaccades, but a normal error rate in PS and AS tasks. Conversely, PSP patients had an increased antisaccade error rate in both AS and PAS, but a normal prosaccade error rate in PS and PAS tasks. These data suggest that CBD and PD patients are impaired in task switching whereas PSP patients are mainly impaired in saccade inhibition. The DLPFC could be more involved in saccade inhibition and that frontomedial areas (probably the pre-SMA) would be more involved in task switching.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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