Neuroscience 2002 Abstract
| Presentation Number: | 369.5 |
|---|---|
| Abstract Title: | Leptin advances puberty in female monkeys. |
| Authors: |
Rapoport, I. F.*1
; Fisher, J.2
; Livingston, A.2
; Yoda, R.2
; Chikazawa, K.2
; Wilson, M. E.1,2
1Ctr Behavioral Neurosci, Emory Univ, Atlanta, GA 2YNPRC, Emory Univ, Atlanta, GA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Neuroendocrine -- Hypothalamic-pituitary-gonadal axis |
| Session: |
369. Neuroendocrine: puberty, pregnancy, parturition Poster |
| Presentation Time: | Monday, November 4, 2002 1:00 PM-2:00 PM |
| Location: | Hall A2-B3 J-19 |
| Keywords: | sexual development, LH, primate |
The role of leptin as a signal regulating puberty is controversial. Leptin reverses infertility in mice lacking the leptin gene (Nat Gen 1996 137: 3144) and may advance puberty in normal mice (JCI 1997 99: 391). Other reports indicate leptin is only permissive for puberty (Neuroendo 2001 74: 12). Indeed, the pubertal increase in LH is unaffected in juvenile male monkeys given leptin (SFN 2001 #466.9). Since the regulation of puberty differs between male and female primates (J CEM 1995 80: 2094), leptin may affect female puberty despite contrary evidence in males. The present study tested the hypothesis that a nocturnal increase in circulating leptin would advance puberty in female rhesus monkeys. Gonadally-intact females (n = 6) received a daily injection of leptin (30 µg/kg, SC) at 1700 hr from 12 through 24 months of age and were compared to age-matched controls (n = 13). Leptin significantly advanced the onset of secondary sexual characteristics (19.5± .9 vs 21.6± .6 mo, p = .03) and age at menarche (20.5±1.2 vs 22.7 ± 0.4 mo, p = .04) and produced an earlier rise in serum estradiol from prepubertal (<5 pg/ml) to perimenarcial levels (25 – 40 pg/ml). Finally, nocturnal serum levels of bioactive LH were elevated significantly in leptin treated monkeys by 18 mo (0.74 ± 0.21 vs 0.31 ± 0.07 ng/ml, p = 0.02), a difference which persisted through 21 mo (0.98 ± 0.16 vs. 0.52 ± 0.11, p = 0.01). These data suggest that a nocturnal increase in circulating leptin may be an important metabolic signal regulating the developmental increase in LH secretion and the progression of puberty in female monkeys.
Supported by HD39153, HD37583, RR00165 and NSF agreement #IBN-9876754
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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