Neuroscience 2003 Abstract
| Presentation Number: | 293.17 |
|---|---|
| Abstract Title: | Glutamate receptor blockade within basolateral amygdala: effects on social interactions. |
| Authors: |
Malkova, L.*1
; Lower, L. L.1
; Silver, C. C.1
; Gaertner, B. E.1
; Gale, K.1
1Interdisciplinary Program in Neurosci. & Dept. Pharmacol., Georgetown Univ., Washington, DC |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion |
| Session: |
293. Motivation & Cognition Poster |
| Presentation Time: | Sunday, November 9, 2003 1:00 PM-2:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # J39 |
| Keywords: | pigtailed macaque, NMDA, AP7, microinfusions |
Decreased social interactions and an increase in self-directed activity have been observed following bilateral ablation of the entire amygdala in monkeys. Decreased social interactions has also been observed following the selective blockade of GABA-A receptors unilaterally in basolateral amygdala (BLA) (Malkova et al., 2003). Conversely, the activation of GABA-A receptors bilaterally in BLA caused a pronounced increase in affiliative social interactions, such as grooming (Lower et al., SFN Abst 2002). Here we investigated the effects of bilateral microinfusions of the NMDA antagonist, AP7 (20nmol), bilaterally into BLA on social interactions in four familiarized dyads of pigtailed macaques. Using a randomized design, one monkey at a time in each dyad received saline or drug treatment (with at least 3 replications); drug sessions alternated with baseline sessions and changes in behavior occurring during the 2hr following treatment were compared within animals across sessions. Significant (p<0.05) changes in general activity, including increased passivity and decreased locomotion were observed after AP7 treatment in all subjects. However, although initiation of social approach increased significantly (p<0.05), there was no increase in total social contact in the dyads. Initial results with application of NBQX (20nmol), a non-NMDA receptor antagonist, did not differ from those obtained with AP7. Thus, in contrast to the effects of GABA receptor activation, the blockade of ionotropic glutamate receptors in BLA is not sufficient to enhance affiliative behavior, suggesting that another source of excitatory drive must contribute to the regulation of BLA-mediated effects on social interaction.
Supported by NIH grants HD39937, MH67414, NS20576
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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