Neuroscience 2005 Abstract
| Presentation Number: | 318.2 |
|---|---|
| Abstract Title: | Neural correlates of instrumental feature-negative discrimination in rabbits. |
| Authors: |
Burhans, L. B.*1
; Olson, A. K.2
; Gabriel, M.1,2
1Neuroscience Program, Univ. of Illinois, Urbana, IL 2Psychology Dept., Univ. of Illinois, Urbana, IL |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning and memory: Physiology and imaging |
| Session: |
318. Pavlovian Conditioning Poster |
| Presentation Time: | Sunday, November 13, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # RR19 |
| Keywords: | conditioned inhibition, medial geniculate, cingulate cortex, anterior ventral thalamus |
Previous work has demonstrated that rabbits can develop conditioned inhibition in an instrumental feature-negative discrimination (FND) task, wherein rabbits learn to produce an avoidance response to a visual stimulus (A+) while learning to withhold that response when A+ is presented in compound with an auditory stimulus (X-) (Barnes et al., 2002 SFN Abstract Viewer, Program No. 676.6). The following study investigated the neural correlates of conditioned inhibition by examining associative (training-induced) changes in neuronal activity in various sensory and limbic areas during acquisition of FND. The goal was to identify brain areas in which information about A+ and X- could converge to inhibit the conditioned avoidance response normally elicited by A+ alone. The results pointed to the medial geniculate and anterior ventral nuclei of the thalamus as the strongest candidates for the neural correlates of conditioned inhibition. Other areas exhibiting associative changes in activity included the cingulate cortex, superior colliculus, and lateral geniculate nucleus of the thalamus. The results favored a model of early convergence, in which associative information about the conditioned excitor (A+) and the conditioned inhibitor (X-) converges in sensory and limbic areas early in the millisecond time series following stimulus onset. The results also provided evidence that conditioned inhibition is encoded by both inhibitory and excitatory processes in the brain.
Supported by NINDS grant 5R01NS036591-07 to MG.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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