Neuroscience 2002 Abstract
| Presentation Number: | 361.20 |
|---|---|
| Abstract Title: | MRI BASED MORPHOMETRIC ANALYSIS OF HUMAN BRAINSTEM. |
| Authors: |
Schmahmann, J. D.*1
; Hodge, S. M.1
; Breiter, H. C.1
; Haselgrove, C.1
; Kennedy, D. N.1
; Dale, A.1
; Fischl, B.1
; Sonricker, A. L.1
; Dieterich, M. E.1
; Boriel, D. L.1
; Hui, K. K. A.1
; DaSilva, A. F. M.1
; Borsook, D.1
; Bacerra, L.1
; Caviness, V. S.1
; Makris, N.1
1Neurology, Mass General Hospital, Boston, MA |
| Primary Theme and Topics |
Motor Systems - Brainstem |
| Secondary Theme and Topics | Sensory Systems<br />- Anatomy |
| Session: |
361. Brainstem Poster |
| Presentation Time: | Monday, November 4, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 F-70 |
| Keywords: | BRAIN STEM, BRAIN IMAGING, MORPHOMETRY, FMRI |
Precise definitions of the anatomic subdivisions of the brainstem are required for structural and functional imaging studies of the brainstem. Localization of functional activation is aided by this precise mapping of function onto structure. In addition, brainstem abnormalities may be characterized in terms of their effects on brainstem function and volume. We describe a parcellation system of the human brainstem based upon neuroanatomy and which conserves the topographic uniqueness of the individual brain. METHOD: Based upon a set of topographical landmarks, we have defined a system for parcellation of the human brainstem into well-defined, closed areas or parcellation units (PUs). To this end, 10 delimiting planes were identified. To apply this method to T-1 weighted anatomic MR images, brainstem exterior and peduncular borders were defined, planes were identified using a cross-referential morphometric tool, and brainstem subdivision was performed. The resulting segmentation served as the basis for morphometric and localization functions. RESULTS: The entire brainstem was parcellated into 14 PUs per side of the brainstem (right and left). Specifically, the midbrain was divided into 6 PUs, the pons into 4 PUs, and the medulla into 4 PUs. We present the volumetric analysis for one individual. We also present the localization of brainstem activation in studies of cocaine, acupuncture, and the stimulation of the trigeminal nerve.
Supported by NARSAD, ALSA
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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