Neuroscience 2001 Abstract
| Presentation Number: | 345.12 |
|---|---|
| Abstract Title: | Event-related functional magnetic resonance imaging in awake macaque monkeys performing oculomotor tasks. |
| Authors: |
Hasegawa, I.*1
; Koyama, M.1
; Nakahara, K.1
; Morita, M.1
; Hayashi, T.1
; Fukushima, T.1
; Miyashita, Y.1
1Department of Physiology, The University of Tokyo Scool of Medicine, Tokyo, Japan |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Motor Systems<br />- Oculomotor<br />-- Saccadic eye movement |
| Session: |
345. Animal cognition and behavior: learning and memory--physiology and imaging Slide |
| Presentation Time: | Monday, November 12, 2001 3:45 PM-4:00 PM |
| Location: | Room 1B |
| Keywords: |
We used event-related functional magnetic resonance imaging (fMRI) to examine activations of the distributed neural systems for the oculomotor control in awake macaque monkeys. The monkeys (macaca fuscata) were trained to perform fixation and saccade tasks in a 1.5T or 4.7T MRI scanner. The eye positions of the animals were monitored with an infrared-sensitive CCD camera. During fMRI session, the fixation trial and saccade trial were pseudorandomly interleaved. On fixation trials, the animals must keep fixation within 1.5 degree of the central spot. On saccade trials, they were required to make saccade to one of the eight peripheral positions at the eccentricity of ten degrees (Fukushima et al, Soc. Neurosci. Abstr. 2000). Standard T2*-weighted echo-planar imaging protocols (Hayashi et al. Eur. J. Neurosci. 1999) were used to obtain the blood oxygenation level-dependent signal. The time series data were analyzed with SPM99, assigning event-related contrasts for different types of trials. We found focal activations in periarcuate and intraparietal regions on saccade trials compared to fixation trials. Saccade directed to one visual hemifield tended to preferentially activate the contralateral hemisphere than the ipsilateral hemisphere. The results appear to be consistent with previous electrophysiological studies in monkeys, as well as functional brain imaging studies in humans. This study shows the feasibility of the event-related fMRI technique in mapping multiple oculomotor areas in awake monkeys.
Supported by Ministry for Education, Culture, Sports, Science and Technology of Japan (11680803, 07102006)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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