Neuroscience 2002 Abstract
| Presentation Number: | 344.12 |
|---|---|
| Abstract Title: | Dopaminergic modulation of EPSP dynamics in interneurons from monkey dorsolateral prefrontal cortex. |
| Authors: |
Li, Z.*1
; Gonzalez-Burgos, G.2
; Kroener, S.2
; Seamans, J. K.1
; Lewis, D. A.2,3
; Barrionuevo, G.2
1Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 2Neuroscience, University of Pittsburgh, Pittsburgh, PA 3Psychiatry, University of Pittsburgh, Pittsburgh, PA |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Synaptic Transmission -- Postsynaptic mechanisms: Excitatory |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- Synaptic Plasticity<br />-- Other |
| Session: |
344. Synaptic transmission: postsynaptic mechanisms--excitatory III Poster |
| Presentation Time: | Monday, November 4, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 C-98 |
| Keywords: | DOPAMINE, EPSP Dynamics, Short-term plasticity, working memory |
In pyramidal cells from rat prefrontal cortex, Dopamine (DA) modulates the response of excitatory synaptic inputs to repetitive presynaptic activation (Seamans et al. PNAS 2001). To examine whether DA also modulates EPSP dynamics in local circuits of layers 2/3 in monkey dorsolateral prefrontal cortex (areas 9 and 46), we examined the effects of DA on trains of EPSPs recorded from Fast Spiking (FS) interneurons. As we reported previously (SFN 2001 Abstr 729.15), during 20 Hz-10 stimulus trains, EPSPs in FS cells depress with little temporal summation. DA (10-50 µM) or D1 agonists (SKF81297 or SKF38393, 10 µM) reduced the amplitude of the first EPSP in the trains (EPSP(1)) and increased the EPSP(10)/EPSP(1) ratio, apparently reducing depression. Decreasing probability of release by reducing the external Ca2+/Mg2+ ratio also reduced EPSP(1) amplitude but only partially mimicked the increase in EPSP(10)/EPSP(1) ratio by DA. A higher EPSP(10)/EPSP(1) ratio could be mediated by modulation of NMDA currents, since single NMDA EPSCs evoked in interneurons were enhanced by SKF81297. In both rat pyramidal cells and in preliminary experiments in primate interneurons, NMDA blockade with AP5 (50 µM) did not affect EPSP(1) nor the EPSP(10)/ EPSP(1) ratio in control conditions, suggesting that if DA modulates EPSP trains via NMDA receptors, then it must be increasing the NMDA conductance above levels that were undetectable prior to modulation.
Supported by MH51234, MH 45156 and a NARSAD Young Investigator Award to G. Gonzalez-Burgos
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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