Neuroscience 2001 Abstract
| Presentation Number: | 323.5 |
|---|---|
| Abstract Title: | Comparison of N-Acetyl Aspartate Losses in Hippocampus and Cortex of Alzheimer's Disease and Ischemic Vascular Dementia. |
| Authors: |
Schuff, N.*1,2
; Du, A. T.1,2
; Capizzano, A. A.1,2
; Jagust, W. J.3
; Yaffe, K.1,2
; Chui, H. C.4
; Rule, R. R.1,2
; Weiner, M. W.1,2
1Radiology, UCSF, San Francisco, CA 2Magnetic Resonance Unit, DVAMC, San Francisco, CA 3Neurology, UCD, Davis, CA 4Neurology, USC, Los Angeles, CA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimers Disease: Other |
| Session: |
323. Neurodegenerative disorders: Alzheimer's disease--imaging and pathology I Poster |
| Presentation Time: | Monday, November 12, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall XX-39 |
| Keywords: | MRI, MRSI |
Goals: 1) to evaluate region, sex, and age effects on Nacetyl aspartate [NAA a neuronal marker] in demented subjects and controls, 2) to determine relationships between [NAA] in hippocampus and cortex, and 3) to test the extent to which [NAA] and MRI predict dementia.
MRSI and MRI studies were performed on 55 Alzheimer's disease (AD), 13subcortical ischemic vascular dementia (SIVD) patients and 54controls. In AD, marked [NAA] reductions occurred in the hippocampus and parietal cortex, while frontal cortex was spared. [NAA] reduction in SIVD occurred in both, parietal and frontal cortex, while hippocampus was spared. [NAA] differences between hippocampus and cortex were highly significant (p< 0.0001) in each group. AD and SIVD had different levels of hippocampal atrophy. Finally, a logistic regression model showed that NAA together with MRI significantly improved classification of AD and SIVD from controls. We conclude that AD and SIVD exhibit different patterns of regional [NAA] reduction, consistent with pathology.
MRSI and MRI studies were performed on 55 Alzheimer's disease (AD), 13subcortical ischemic vascular dementia (SIVD) patients and 54controls. In AD, marked [NAA] reductions occurred in the hippocampus and parietal cortex, while frontal cortex was spared. [NAA] reduction in SIVD occurred in both, parietal and frontal cortex, while hippocampus was spared. [NAA] differences between hippocampus and cortex were highly significant (p< 0.0001) in each group. AD and SIVD had different levels of hippocampal atrophy. Finally, a logistic regression model showed that NAA together with MRI significantly improved classification of AD and SIVD from controls. We conclude that AD and SIVD exhibit different patterns of regional [NAA] reduction, consistent with pathology.
Supported by NIH AG10897, AG12435, and the Alzheimer's Association.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
