Neuroscience 2002 Abstract
| Presentation Number: | 324.2 |
|---|---|
| Abstract Title: | Extraction of neural correlates of recency judgment using event-related functional MRI. |
| Authors: |
Konishi, S.*1
; Uchida, I.1
; Okuaki, T.2
; Machida, T.2
; Shirouzu, I.2
; Miyashita, Y.1
1Dept Physiol, Univ Tokyo Sch Med, Tokyo, Japan 2Dept Radiol, Kanto Medical Center NTT EC, Tokyo, Japan |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Learning and memory |
| Session: |
324. Human cognition and behavior: learning and memory V Slide |
| Presentation Time: | Monday, November 4, 2002 1:15 PM-1:30 PM |
| Location: | Room 207A |
| Keywords: | frontal, memory, context, recognition |
Neuropsychological studies of humans and monkeys have provided evidence that the damage to the prefrontal cortex impairs the ability to discriminate the order of events sequentially presented during recency judgment paradigms. Previous neuroimaging studies investigated the temporal-order memory by contrasting it with item memory, and revealed that frontal activation was stronger during the temporal-order memory than during the item memory. The present functional magnetic resonance imaging (fMRI) study explored the precise neural correlates of the temporal-order retrieval per se using an intra-paradigm comparison within a recency judgment paradigm. In this paradigm, after subjects studied a list of words sequentially, they were presented with two of the studied words simultaneously and were asked which of the two words were studied more recently. Two types of such retrieval trials with varied amount of demands for the recency judgment were intermixed and compared using event-related fMRI. The comparison of high versus low demand trials revealed brain regions whose activation modulated based on the demands for the recency judgment. Prominent activation was observed in multiple regions in middle and inferior lateral prefrontal cortex. The modulation of brain activity in these regions suggests a detailed pathway that is engaged during the contextual retrieval.
Supported by a Grant-in-Aid for Specially Promoted Research (07102006) from MEXT of Japan
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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