Neuroscience 2002 Abstract
| Presentation Number: | 320.10 |
|---|---|
| Abstract Title: | LOSS OF VAGAL INTRAMUSCULAR MECHANORECEPTORS IN <i>STEEL</i> MUTANT MICE IS ASSOCIATED WITH ALTERED SHORT-TERM SATIETY. |
| Authors: |
Fox, E. A.*1
; Byerly, M. S.1
; Chi, M. M.1
; Phillips, R. J.1
; Powley, T. L.1
1Dept Psycholog Sci, Purdue Univ, West Lafayette, IN |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Regulation of Food Intake and Body Weight |
| Session: |
320. Regulation of food intake and body weight: leptin and peptide mediated mechanisms Slide |
| Presentation Time: | Monday, November 4, 2002 3:15 PM-3:30 PM |
| Location: | Room 203A |
| Keywords: | vagal afferents, intramuscular arrays, interstitial cells of Cajal, food intake |
Vagal intramuscular arrays (IMAs) in the forestomach appear to transduce tension/stretch through interactions with smooth muscle and intramuscular interstitial cells of Cajal (ICC-IMs), and IMAs are thought to regulate digestive function and inform the brain about such activity. Mice with steel factor or c-Kit mutations have loss of ICC-IMs and IMAs (Burns et al., PNAS, 93, 1996; Fox et al., 1999, SFN mtg; Anat Embryol, 204, 2001). To examine whether loss of the smooth muscle/ICC-IM/IMA signaling pathway is associated with altered ingestive behavior, meal patterns of steel mutants and wild-type mice fed novel pelleted (20mg, Bioserv) or liquid (Isocal, Mead Johnson) diets were monitored for two weeks. Data obtained after feeding patterns stabilized revealed selective changes in short term satiety: meal size in the steel mutants was reduced by 20%, and this was compensated by a 40% increase in meal frequency for solid food; changes were less pronounced on liquid diet. In contrast to these short-term changes, long-term controls of energy balance were intact, insofar as mutants and controls did not differ in body weight regulation or total daily food intake. A parsimonious hypothesis to account for the altered meal patterns of steel mutants is that the smooth muscle/ICC-IM/IMA signaling pathway participates in the accommodation reflex: upon detection of food entering the stomach it relaxes to accommodate the imminent food accumulation. Impairment of this reflex would result in reduced stomach volume hence smaller meals. Alternative explanations are also considered.
Supported by NIH DK27627
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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