Neuroscience 2004 Abstract
| Presentation Number: | 240.7 |
|---|---|
| Abstract Title: | <I>in vivo</I> analysis of cortical myeloarchitecture using high-resolution MRI and cortical surfaces. |
| Authors: |
Thomas, A. G.*1
; Heekeren, H. R.1
; Saad, Z.2
; Bandettini, P. A.1
; Marrett, S.1
1Functional MRI Facility, NIMH/NIH/DHHS, Bethesda, MD 2MD, Bldg 10, Room 1D80 10 Center Dr, 20892-1148, |
| Primary Theme and Topics |
Techniques in Neuroscience - Staining, tracing and imaging techniques |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Anatomy |
| Session: |
240. Imaging Techniques: fMRI, BOLD, and Other Poster |
| Presentation Time: | Sunday, October 24, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # GGG19 |
| Keywords: | VOXEL BASED MORHPOMETRY, MORPHOMETRY, COMPUTATIONAL NEUROANATOMY, MRI |
The distribution of myelin in the human brain provides a basis for the parcellation of cortex into distinct anatomical and functional subunits. in-vivo studies have shown that myeloarchitectural features such as the stria of Gennari can be found within primary visual cortex (Clark et al (1991), Barbiere et al (2002)) and that more subtle features can be detected in extrastriate cortex (Walters et al (2003). Analysis of this data usually requires time-consuming manual study to determine the boundaries between white matter and gray matter and to carry out densitometric analysis. Accurate cortical surfaces allow line density profiles to be automatically and objectively generated and analyzed. Here we present an early example of this technique on high resolution MR images acquired using an MP-RAGE sequence with occipital or flexible bi-temporal phased-array (Nova Medical). Voxel size was approximately 0.3 x 0.3 mm in plane with a slice thickness of 0.5mm-0.9mm. Cortical surfaces were computed using FreeSurfer while further analysis was done with MINC tools and AFNI/SUMA. The figure below shows the average of 330 line density profiles through primary auditory cortex (PAC) and a coronal slice of PAC from which the profiles were generated. Large variance close to the pial surface (70-100%) is partially due to inaccuracy in pial surface extractions. Refinement of this method shows promise for an automatic and comprehensive densitometric analysis of high-resolution MRI data.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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