Neuroscience 2003 Abstract
| Presentation Number: | 240.14 |
|---|---|
| Abstract Title: | apoE ε4 dose effect on gray matter atrophy in cognitively normal adults. |
| Authors: |
Alexander, G. E.*1
; Chen, K.1,2
; Reiman, E. M.2
; Caselli, R. J.3
; Lewis, D. J.1
; Jothen, J. L.1
; Prouty, A.
; Bandy, D.
1Ariz State Univ, Tempe, AZ 2AZ, PO Box 871104, 85287-1104, 3USA, PO Box 871104, 85287-1104, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: Other |
| Session: |
240. Alzheimer's Disease: Cognition & Neuropharmacology Slide |
| Presentation Time: | Sunday, November 9, 2003 4:15 PM-4:15 PM |
| Location: | Morial Convention Center - Room 395 |
| Keywords: | ALZHEIMER, APOLIPOPROTEIN E, MRI, MORPHOMETRY |
Cognitively normal apolipoprotein E (APOE) ε4 carriers have greater cerebral hypometabolism than ε4 non-carriers in posterior cingulate, parietal, temporal, and frontal brain regions. To evaluate the dose-dependent effects of this common Alzheimer’s disease (AD) susceptibility gene on regional brain atrophy, we investigated the relation between APOE ε4 gene dose and gray matter concentration in 113 cognitively normal late middle-aged adults. T1-weighted volumetric magnetic resonance imaging (MRI) scans were acquired in 21 ε4 homozygotes (mean age=57±5 years; 6M/15F; Mini-Mental State Exam (MMSE)=29.6±0.7) and 33 ε4 heterozygotes (mean age=57±4 years; 8M/25F; MMSE=29.8±0.4) with reported family histories of AD and no cognitive problems or complaints and 59 demographically matched ε4 non-carriers (mean age=57±5 years; 20M/39F; MMSE=29.7±0.6). Voxel-based morphometry with SPM99 was used to transform the brain scans to a standard brain atlas, to segment them into gray matter images, and to create a statistical probability map of correlations between gray matter concentration and ε4 dose. Significance was determined with a priori small volume correction. Higher ε4 gene dose was associated with greater reductions in gray matter concentration in posterior cingulate cortex (3.4≦z≦3.9), regions in bilateral parahippocampal/lingual gyri (3.4≦z≦3.9), a left parietal region (z=3.2), and a region in anterior cingulate/medial frontal cortex (z=3.8). Among cognitively normal late middle-aged individuals, a higher dose of the ε4 allele was associated with greater gray matter reductions in brain regions known to be affected early in AD. These findings provide further support for the use of voxel-based MRI morphometry to help detect the earliest effects of AD on the brain, even before the onset of cognitive symptoms.
Supported by NIH; AZ ARC & ADC
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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