Neuroscience 2000 Abstract
| Presentation Number: | 285.12 |
|---|---|
| Abstract Title: | Failure of cannabidiol to promote neuroprotection following global cerebral ischemia. |
| Authors: |
Rosenthal, R. E.*1
; Haywood, Y.1
; Axelrod, J.2
; Hampson, A.2
1Emergency Med, George Washington Univ Med Ctr, Washington, DC 2Lab Cell Molec Reg, NIMH, Bethesda, MD |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 134. Ischemia: neuroprotection and tolerance |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 136. Ischemia: functional outcome |
| Session: |
285. Ischemia: neuroprotection and tolerance VI Poster |
| Presentation Time: | Monday, November 6, 2000 11:00 AM-12:00 PM |
| Location: | Hall G-J |
| Keywords: | CANNABINOIDS, BEHAVIOR** |
Objective: Cannabidiol (CBD) a non-psychoactive component of marijuana, prevents glutamate-mediated neurotoxicity and reactive oxygen species induced cell death in neuronal culture. This study was designed to evaluate the neuroprotective efficacy of CBD in a model of global cerebral ischemia in dogs. Methods: 18 adult female Beagles underwent 10 min Cardiac Arrest. then restoration of spontaneous circulation followed by 24 hours of intensive care. Immediately following resuscitation, half of the animals received CBD (5 mg/kg IV) while the others received drug vehicle only. 23 hr after resuscitation, dogs were awakened and examined for neurologic deficit by blinded examiners using a standardized neurologic deficit scoring (NDS) system, measuring level of consciousness, respiration, cranial nerves, motor/sensory function and behavior. (0 = nl, 100 = brain death). NDS has previously been shown to correlate with neuronal histopathology. Results: No differences were noted between experimental groups in terms of NDS measured at 24 hr. Dogs in both groups demonstrated moderate neurologic impairment. (NDS = 39.6+/-6.6 CBD; 38.0+/-4.5 Control; p=0.9648) Most animals appeared stuporous, few able to right themselves spontaneously. Several demonstrated stereotypical, purposeless running movements. Conclusions: Despite promising results in neuronal cell culture, cannabidiol failed to demonstrate neuroprotection in this clinically relevant model of global cerebral ischemia.
Supported by Ronald Reagan Institute of Emergency Medicine
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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