Neuroscience 2001 Abstract
| Presentation Number: | 293.2 |
|---|---|
| Abstract Title: | MRI ATLAS OF THE HUMAN CEREBELLAR NUCLEI. |
| Authors: |
Dimitrova, A.*1
; Weber, J.2
; Redies, C.3
; Maschke, M.1
; Kindsvater, K.1
; Kolb, F. P.4
; Forsting, M.2
; Diener, H. C.1
; Timmann, D.1
1Dept. of Neurology, Univ. of Essen, Essen, Germany 2Dept. of Neuroradiology, Univ. of Essen, Essen, Germany 3Dept. of Anatomy, Univ. of Essen, Essen, Germany 4Dept. of Physiology, Univ. of Munich, Munich, Germany |
| Primary Theme and Topics |
Motor Systems - Cerebellum -- Nuclei |
| Secondary Theme and Topics | Motor Systems<br />- Anatomy |
| Session: |
293. Cerebellum: nuclei Poster |
| Presentation Time: | Monday, November 12, 2001 9:00 AM-10:00 AM |
| Location: | Exhibit Hall KK-10 |
| Keywords: | Cerebellum, Neuroimaging, Motor Control |
The differential role of the cerebellar cortex and nuclei has rarely been addressed in human lesion and functional brain imaging studies. One important reason is the difficulty of defining the localization of the cerebellar nuclei and extent of possible lesions based on CT or MR scans. The present MRI investigation was specifically designed to study the detailed anatomy of the deep cerebellar nuclei. Both basal ganglia and cerebellar nuclei show an increasing iron content in healthy human subjects with increasing age. Clusters of iron are paramagnetic and, therefore, tend to cause local inhomogenities in a magnetic field. The iron-induced susceptibility artefacts were used to visualize the cerebellar nuclei as hypointensities on MR images.
A three-dimensional axial volume of the cerebellum was acquired using a multigradient echo sequence on a Siemens Sonata 1.5 Tesla MR (FOV = 220 mm, number of partitions = 84, voxel size = 1.15 x 0.86 x 1.00 mm3, TR/TE = 70/50 ms, flip angle =8 degrees). Each volume was registered, resampled to 1.00 x 1.00 x 1.00 mm3 voxel size and spatially normalized into a standard proportional stereotaxic space (the Montreal Neurologic Institute (MNI) brain-averaged space) using SPM99. A three-dimensional atlas of the dentate, interposed and fastigial nuclei will be presented in MNI-space coordinates based on findings in a healthy 26-year-old female. Localization of cerebellar nuclei were confirmed by comparison with postmortem MR and histological microsections of another cerebellum.
A three-dimensional axial volume of the cerebellum was acquired using a multigradient echo sequence on a Siemens Sonata 1.5 Tesla MR (FOV = 220 mm, number of partitions = 84, voxel size = 1.15 x 0.86 x 1.00 mm3, TR/TE = 70/50 ms, flip angle =8 degrees). Each volume was registered, resampled to 1.00 x 1.00 x 1.00 mm3 voxel size and spatially normalized into a standard proportional stereotaxic space (the Montreal Neurologic Institute (MNI) brain-averaged space) using SPM99. A three-dimensional atlas of the dentate, interposed and fastigial nuclei will be presented in MNI-space coordinates based on findings in a healthy 26-year-old female. Localization of cerebellar nuclei were confirmed by comparison with postmortem MR and histological microsections of another cerebellum.
Supported by DFG Ti 239/2-3
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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