Neuroscience 2003 Abstract
| Presentation Number: | 216.4 |
|---|---|
| Abstract Title: | Comparisons of white matter damage in HIV and normal aging on MRI. |
| Authors: |
Archibald, S. L.*1,2
; Fennema-Notestine, C.1,2
; Gamst, A. C.1
; Grant, I.1,2
; Jernigan, T. L.1,2
1Psychiatry, UCSD, La Jolla, CA 2CA, 9500 Gilman Drive, 92093-0949, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neuroimmunology and Infections |
| Session: |
216. Neuroimmunology and Infections: HIV & the CNS Poster |
| Presentation Time: | Sunday, November 9, 2003 11:00 AM-12:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # VV18 |
| Keywords: | neuroimaging, morphometry |
Significant white matter signal alteration is a frequent finding in both individuals with HIV (HIV+) and normal elderly subjects seronegative for HIV (HIV-). As the incidence of HIV in older individuals increases, the detection of white matter abnormalities (WMA) related to HIV in the elderly presents a challenge. The present study compared WMA in these groups using MRI morphometry. Analyses were performed on 122 HIV- subjects aged 20 to 99 years, and 42 HIV+ subjects aged 25 to 55 years. Volumes of WMA in the HIV+ group resembled those of HIV- individuals who were more than 30 years older. To investigate whether there were regional differences in WMA, three groups were compared: a younger HIV- group aged 25 to 50 (HIV-Y), HIV+ subjects in this age range (HIV+Y), and HIV- individuals aged 60-75 (HIV-O). Both HIV-O and HIV+Y groups exhibited significant increases in the volume of WMA, relative to the HIV-Y group, across multiple regions including the 4 cerebral lobes and a region of deep white matter surrounding the basal ganglia. We then compared the subjects in the HIV+Y and HIV-O groups who had evidence of WMA above the median value: 19 HIV+ and 11 HIV-O subjects met this criterion. Group means of WMA were compared using t-tests for the total cerebrum, the cerebral lobes, and the deep region. Although the volumes for total WMA were the same in both groups, there was evidence that the deep white matter region was disproportionately affected in the HIV+ group (p<.01). As the incidence of HIV increases in the elderly it is important to distinguish damage associated with HIV/AIDS from that occurring with normal aging. These results suggest that while the amount of white matter damage occurring in HIV and normal aging may be similar, the regional patterns of these abnormalities may distinguish them.
Supported by DA12065; HNRC MH45294 & MH62512; MH64905; ADRC AGO5131; AG04085 and DVA Medical Research Service.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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