Neuroscience 2003 Abstract
| Presentation Number: | 203.16 |
|---|---|
| Abstract Title: | MRI-derived right entorhinal volume is a good predictor of conversion from MCI to AD. |
| Authors: |
Stoub, T. R.*1
; Bulgakova, M.5
; Wilson, R. S.1,2,3
; Bennett, D. A.1,3
; Leurgans, S.1
; Wuu, J.1
; Turner, D. A.4
; deToledo-Morrell, L.1,2
1Neurological Sci., Rush Univ., Chicago, IL 2Psychology, Rush Univ., Chicago, IL 3Rush Alzheimer’s Dis. Ctr., Rush Univ., Chicago, IL 4Diagnos. Radiology and Nuclear Med., Rush Univ., Chicago, IL 5AZ, 1653 W Congress Pkwy, 60612, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Aging<br />-- Other |
| Session: |
203. Alzheimer's Disease: Imaging & Neuropathology Poster |
| Presentation Time: | Sunday, November 9, 2003 11:00 AM-12:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # JJ2 |
| Keywords: | HIPPOCAMPUS, NEUROIMAGING, TEMPORAL LOBE, VOLUMETRIC MRI |
Comparisons of alterations in the anatomy of the entorhinal cortex (EC) and hippocampal formation (HF) in elderly individuals are of great interest, since these regions are pathologically involved in the very early stages of Alzheimer's disease (AD) and could, potentially, identify those at risk for developing AD. In the present study, 27 patients diagnosed with mild cognitive impairment (MCI-memory) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 converted to AD during a 36 month-period following the baseline clinical evaluation. EC and HF volumes were derived separately for each hemisphere from T1-weighted coronal images reformatted to be perpendicular to the long axis of the HF. To control for individual differences in brain size, regions of interest were divided by total intracranial volume (normalized). Logistic regression models showed that although both normalized entorhinal and hippocampal volumes were independent predictors of conversion [χ²(1)=7.3, p=0.007 and χ²(1)=6.2, p=0.013 respectively], it was the right hemisphere EC volume that best predicted conversion [χ²(1)=9.6, p=0.0021], showing a concordance rate of 93.5%. Left EC volume did not add significantly to predictions based on the right EC (p=0.70); however, adding right EC volume to the model significantly improved predictions based on left EC volume [χ²(1)=5.4, p=0.02]. In contrast, right and left HF volumes were equivalent predictors of conversion. These results indicate that the extent of atrophy of mesial temporal lobe structures can identify those at risk for AD.
Supported by AG09466, AG10161 & AG17917
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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