Neuroscience 2004 Abstract
| Presentation Number: | 207.3 |
|---|---|
| Abstract Title: | Synchronous oscillations in striatal local field potentials correlate with movement initiation. |
| Authors: |
Masimore, B.*1
; Schmitzer-Torbert, N. C.2
; Jackson, J. C.2
; Kakalios, J.1
; Redish, A. D.2
1Dept Physics, Univ Minnesota, Minneapolis, MN 2Dept Neurosci., Univ Minnesota, Minneapolis, MN |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Associative, nonassociative and skill learning & memory systems |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Learning & memory: Physiology and imaging |
| Session: |
207. Reward Mechanisms Poster |
| Presentation Time: | Sunday, October 24, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # MM32 |
| Keywords: | STRIATUM, local field potential, SYNCHRONY, MOTOR CONTROL |
Previous studies (Berke et al, SFN 2003, Masimore et al, SFN 2003) identified an approximately 50Hz transient oscillation in local field potentials (LFPs) in rodent striatum . LFPs were recorded from tetrodes chronically implanted in the striatum while rats (n=11) performed sequence-learning, navigation, and operant-conditioning tasks. Interactions between frequencies were calculated via correlation coefficients of Fourier transformed signals. Areas of high correlation indicate that a single process is strongly contributing to those frequencies (Masimore et al., in press, J Neurosci Methods).
The tasks were divided into behaviorally significant sections. Different task regions showed strikingly different correlations, with the 50Hz correlation occurring strongly in areas where the animal typically initiated ballistic movements. The 50Hz signal was much weaker in areas where the animal was moving smoothly.
In data from 4 rats, the events were strong enough to be individually identified. They were characterized by a transient synchrony across LFPs (frequency of 50-55 Hz, average duration of 136 ms). These events occurred at the precise time in which the animals initiated movement. A peri-event histogram of speed aligned to time of the transient event indicated a sharp increase in speed from zero to a significant non-zero value aligned with the transient 50 Hz signal.
An identified motor initiation signal may have great implications for our understanding of disorders such as Parkinson's and Huntington's disease. These disorders are known to involve the striatum and key symptoms include difficulty in voluntary control of motor initiation. Synchronous oscillatory events such as the one identified here may be involved.
The tasks were divided into behaviorally significant sections. Different task regions showed strikingly different correlations, with the 50Hz correlation occurring strongly in areas where the animal typically initiated ballistic movements. The 50Hz signal was much weaker in areas where the animal was moving smoothly.
In data from 4 rats, the events were strong enough to be individually identified. They were characterized by a transient synchrony across LFPs (frequency of 50-55 Hz, average duration of 136 ms). These events occurred at the precise time in which the animals initiated movement. A peri-event histogram of speed aligned to time of the transient event indicated a sharp increase in speed from zero to a significant non-zero value aligned with the transient 50 Hz signal.
An identified motor initiation signal may have great implications for our understanding of disorders such as Parkinson's and Huntington's disease. These disorders are known to involve the striatum and key symptoms include difficulty in voluntary control of motor initiation. Synchronous oscillatory events such as the one identified here may be involved.
Supported by NSF IGERT #9870633, NIH MH68029, U of Minn IRCSA grant.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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