Neuroscience 2003 Abstract
| Presentation Number: | 202.8 |
|---|---|
| Abstract Title: | Genetic association within the IDE region on chromsome 10 - the consortium on Alzheimer's genetics (CAG). |
| Authors: |
Mullin, K. M.*1
; Bertram, L.1
; Moscarillo, T.2
; Becker, K. D.3
; Wang, C.3
; Growdon, J.4
; Blacker, D.2
; Tanzi, R. E.1
; The CAG Study Group, &.4
1Neurol., Massachusetts Gen. Hosp., Harvard Med. Sch., Charlestown, MA 2MA, CNY 114, 16th Street, 02129, 3USA, CNY 114, 16th Street, 02129, 4Psychiatry, CNY 114, 16th Street, 02129, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: Other |
| Session: |
202. Alzheimer's Disease: Genetics & Biomarkers II Poster |
| Presentation Time: | Sunday, November 9, 2003 11:00 AM-12:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # HH1 |
| Keywords: | GENETICS, ASSOCIATION, ALZHEIMER |
The Consortium on Alzheimer's Genetics (CAG) is a multicenter collaborative research project aimed at identifying genes involved in Alzheimer's Disease (AD). Over the past four years, we have collected almost 700 DNA samples from 318 families with at least one sibling-pair discordant for AD. Initial genotyping efforts focused on APOE and the putative AD locus on chromosome 10q24. The gene for insulin-degrading enzyme (IDE), which lies in this region, has been shown to degrade Aβ and the APP intracellular domain (AICD) in vitro. These results were recently confirmed in vivo in IDE knock-out mice (Farris et al, 2003). The IDE gene has also been found to be genetically associated with AD in an earlier family-based study (Bertram et al, SFN 2002). Using the first 155 families in the CAG sample, we employed the Family Based Association Test package to test for association with AD, and conditional logistic regression to estimate the magnitude of risk for AD for APOE ε4 and multiple SNPS in IDE. We observed the expected effect for the APOE ε4 allele (ORs ranging from 3.5 to 12.4, P<0.0001), and also observed significant association for multiple SNPs and SNP haplotypes in the IDE region (ORs ranging from 2.3 to 4.5, P<0.01). This independent replication of the previously reported genetic association between IDE and AD in a second family sample lends further support to the involvement of this intriguing candidate gene in AD neuropathogenesis.
Supported by NIMH, NIA, HCNR
<B>Conflict of Interest:</B> LB, AJS, CW, KDB & RET have a financial interest in Neurogenetics, Inc.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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