Neuroscience 2004 Abstract
| Presentation Number: | 201.9 |
|---|---|
| Abstract Title: | Object and spatial perception deficits following medial temporal lobe lesions. |
| Authors: |
Graham, K. S.*1
; Lee, A. C. H.1
; Gaffan, D.2
; Spiers, H.1
; Scahill, V.1
; Hodges, J. R.1
; Buckley, M.2
1Cog. and Brain Sci. Unit, MRC, Cambridge, United Kingdom 2United Kingdom, 15 Chaucer Rd, CB2 2EF, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Learning and long-term memory |
| Session: |
201. Learning and Long-Term Memory III Poster |
| Presentation Time: | Sunday, October 24, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # II23 |
| Keywords: | memory, amnesia, hippocampus, perirhinal cortex |
Animal studies suggest that the perirhinal cortex subserves object perception while the hippocampus plays a role in spatial processing. In support of the former, we previously reported (Lee et al., SFN 2003) that patients with bilateral damage to the hippocampus and perirhinal cortex were significantly impaired on perceptual tasks that placed a significant demand on discriminating feature conjunctions (e.g. oddity judgement for novel faces and objects) but not tasks that could be solved using single features (e.g. oddity judgement for size, shape and colour). Patients with selective bilateral hippocampal lesions performed normally on all of these tests. These findings raised two further questions: (1) whether the findings could be extended into the spatial domain, with hippocampal damage resulting in impaired oddity judgement for spatial scenes and (2) whether problems with face and scene discrimination reflected damage to non-MTL regions (e.g., fusiform face area and parahippocampal place area). To investigate these issues, the patients were asked to perform oddity judgement for faces and scenes presented from the same or different views. In brief, all patients demonstrated intact general perception of faces and scenes when a different face/scene was presented with images of the same distractor face/scene taken from the same view. Notably, however, the hippocampal patients were significantly impaired when the distractor scenes were different views of the same scene (thereby stressing spatial conjunctions), but showed intact performance on a face different view condition. By contrast, the MTL patients showed a significant deficit on both the scene and face different view conditions. These data confirm that MTL regions play distinct roles in object/face (perirhinal cortex) and scene (hippocampus) perception.
Supported by Medical Research Council; Alzheimer's Research Trust
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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