Neuroscience 2003 Abstract
| Presentation Number: | 196.11 |
|---|---|
| Abstract Title: | Language outcome after child-onset unilateral basal ganglia lesions: a combined neuropsychological and MRI study. |
| Authors: |
Rowan, A.*1,2
; Connelly, A.2
; Baldeweg, T.1
; Liegeois, F.1
; Calamante, F.2
; Tournier, D.2
; Vargha-Khadem, F.1
; Gadian, D.2
1Developmental Cognitive Neurosci. Unit, Inst. of Child Hlth., Univ. Col. London, London, United Kingdom 2Radiology & Physics Unit, Inst. of Child Hlth., Univ. Col. London, London, United Kingdom |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Language |
| Session: |
196. Human Cognition and Behavior: Development II Poster |
| Presentation Time: | Sunday, November 9, 2003 10:00 AM-11:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # V8 |
| Keywords: |
Language function was studied in 17 patients with infarctions apparently confined to unilateral basal ganglia and surrounding white matter [10 left hemisphere (LH), 7 right hemisphere (RH)]. Mean age at injury was 7yrs and 4yrs, and mean age at study was 12yrs and 9yrs, for the LH and RH groups respectively. We have previously shown that long-term receptive and expressive language outcome did not differ significantly between the LH and RH groups. The variance in the LH group was, however, much greater than in the RH group. Voxel-based morphometric analyses of structural MRI 3D datasets and MR diffusion tensor imaging data identified regions of grey and white matter density and diffusion anisotropy, outside the site of the infarction and including Broca’s area, that correlated with language performance in the LH group but not in the RH group. Furthermore, the only 3 patients with haemodynamic abnormalities involving left cortical language areas on MR perfusion imaging were the 3 LH patients with poorest language function. To determine whether the greater variance in the LH group might also have been related to differences in reorganisation of language, we assessed fMRI activation in a subset of these patients (LH: n=5; RH: n=3) during covert verb generation. Inferior frontal activation was left-lateralised in all patients regardless of side of injury, suggesting that damage during childhood to the left basal ganglia is not sufficient to induce cross-hemispheric cortical reorganisation. Therefore, additional previously undetected abnormalities beyond the core lesion site remain the most likely explanation for the variance in language outcome after left-sided basal ganglia infarctions in this group of children.
Supported by Child Health Research Appeal Trust & Wellcome Trust
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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