Neuroscience 2001 Abstract
| Presentation Number: | 243.8 |
|---|---|
| Abstract Title: | Enhanced distribution of neural recruitment in obstructive sleep apnea to loaded breathing challenges revealed by functional magnetic resonance imaging (fMRI). |
| Authors: |
Macey, P. M.*1
; Macey, K. E.1
; Henderson, L. A.1
; Woo, M. A.3
; Frysinger, R. C.1
; Valderama, C.1
; Alger, J. R.2
; Harper, R. M.1
1Neurobiology, UCLA, Los Angeles, CA 2Radiological Sciences, UCLA, Los Angeles, CA 3School of Nursing, UCLA, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Biological Rhythms and Sleep |
| Session: |
243. Autonomic: respiratory regulation--rhythm generation and motor output Slide |
| Presentation Time: | Monday, November 12, 2001 9:45 AM-10:00 AM |
| Location: | Room 30C |
| Keywords: | RESPIRATION, LIMBIC SYSTEM, HIPPOCAMPUS, CEREBELLUM |
Although transient airway constrictions occur during sleep both in normal and obstructive sleep apnea (OSA) subjects, neural mechanisms that maintain upper airway patency appear not to be activated, or are recruited with sufficient delay to be ineffective in OSA patients. To evaluate these mechanisms, a series of 20 image slices (25 repetitions, Echo Planar technique) through the entire brain was collected during 1 min baseline and 1.5 min expiratory (8 controls, 12 OSA) and inspiratory (10 Controls, 6 OSA) loading challenges in a GE 1.5T Signa scanner. Ages of Controls were 29-62; OSA ages were 29-66. Images were subjected to fixed effects analysis using the SPM imaging package. Areas recruited in both control and patient groups included deep cerebellar nuclei, putamen, and hippocampus. The OSA group showed significantly more dispersion of areas with signal changes, including the orbital frontal cortex, multiple cerebellar regions, and widespread diencephalic sites. In certain forebrain areas, a delayed onset of signal change occurred in OSA patients in response to the expiratory challenge, despite comparable extent of change. We speculate that OSA patients have lost an essential compensatory system for responding to airway constriction, and must recruit a wider range of neural sites to overcome the airflow disturbance.
Supported by NHLBI HL-60296
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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