Neuroscience 2001 Abstract
| Presentation Number: | 219.2 |
|---|---|
| Abstract Title: | A QUANTITATIVE MRI INVESTIGATION OF ADHD AND CD: DOES CO-MORBIDITY MAKE A DIFFERENCE? |
| Authors: |
Grudnik, J. L.*1
; Bussing, R.2
; Mason, D.2
; Leonard, C. M.3
1Educational Psychology, Univ Florida McKnight Brain Institute, Gainesville, FL 2Psychiatry, Univ Florida McKnight Brain Institute, Gainesville, FL 3Neuroscience, Univ Florida McKnight Brain Institute, Gainesville, FL |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Other |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Attention |
| Session: |
219. Psychiatric disorders: other Poster |
| Presentation Time: | Sunday, November 11, 2001 2:00 PM-3:00 PM |
| Location: | Exhibit Hall ZZ-18 |
| Keywords: | ATTENTION, BRAIN IMAGING, CEREBELLUM, HUMAN |
Attention-Deficit Hyperactivity Disorder (ADHD) is the most common psychiatric disorder among school-aged children, occurring in about 5% of the population. Between 40-70% of these children also portray a persistent pattern of antisocial behavior, referred to as Conduct Disorder (CD). Researchers using MRI to study children with ADHD have consistently attributed core deficits of inattention and impulsivity to frontal-striatal-cerebellar abnormalities; however, no study has investigated the neuroanatomical characteristics of children diagnosed with ADHD co-morbid with CD. This study examined a community sample of 12 children with ADHD (aged 8-12, 7 with CD) and 24 healthy controls matched for age, sex, handedness, and SES. Volume measurements, including right-left asymmetries, were quantified from MRI of the total brain and cerebellar vermis. No significant differences in brain size or asymmetry were found between the groups. Measurements of the left and total posterior superior and inferior lobes of the vermis indicated smaller volumes for ADHD and co-morbid children compared to the controls (p < .05). Children with ADHD also showed a significant rightward asymmetry for the posterior inferior lobes of the vermis, while the controls had a significant leftward asymmetry (p < .05). Analysis of variance demonstrated no significant volumetric differences between the ADHD and co-morbid types. These results suggest ADHD and ADHD co-morbid with CD have similar cerebellar morphology. Future studies will explore the possibility that cortical components of the limbic system differentiate these two groups.
Supported by NICDC RO1 2922 AND RO1 MH57399
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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