Neuroscience 2002 Abstract
| Presentation Number: | 228.7 |
|---|---|
| Abstract Title: | In vivo Detection of Alzheimer's Amyloid Lesions in Transgenic Mice by Magnetic Resonance Imaging. |
| Authors: |
Wadghiri, Y. Z.*1
; Sigurdsson, E. M.3,4
; Li, Y.2
; Elliott, J. I.7,8
; Tang, C. Y.9,10
; Aguilnaldo, G.9,10
; Duff, K.6
; Pappolla, M.11
; Scholtzova, H.2
; Watanabe, M.3
; Turnbull, D. H.1,3,5
; Wisniewski, T.2,3,4
1Skirball Institute of Biomolecular Medicine, New York University, New York, NY 2Dept.Neurol., New York University, New York, NY 3Dept. Pathol., New York University, New York, NY 4Dept. Psych., New York University, New York, NY 5Dept. Radiol., New York University, New York, NY 6Nathan S. Kline Institute, Orangeburg, NY 7Dept. Mol.Biophysics, Yale University, New Haven, CT 8Dept. Biochem., Yale University, New Haven, CT 9Dept. Radiol. , Mt.Sinai Sch.Med., New York, NY 10Dept. Psych., Mt.Sinai Sch.Med., New York, NY 11Dept. Neurol., Univ S.Alabama Med Cent, Mobile, AL |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimers Disease: Other |
| Session: |
228. Neurodegenerative disorders: Alzheimer's disease--imaging studies Slide |
| Presentation Time: | Monday, November 4, 2002 9:30 AM-9:45 AM |
| Location: | Room 315A |
| Keywords: | Imaging, Amyloid, Diagnostic Test, Alzheimer |
The definitive diagnosis of Alzheimer's disease (AD) currently requires post-mortem examination. We present a novel method for the detection of amyloid β (Aβ) plaques by magnetic resonance micro-imaging (μMRI) using transgenic mouse models of AD. This method utilizes Aβ1-40 peptides, which are labeled with either gadolinium (Gd) or monocrystalline iron oxide nanoparticles (MION). When either of these ligands is injected in vivo systemically with mannitol to transiently open the blood-brain-barrier, we are able to image both ex vivo and in vivo the majority of Aβ plaques. No lesions are detected in the non-Tg mice injected with these ligands. Tg mice injected with Aβ not coupled to Gd or MION also showed no lesions. This μMRI approach can be used to monitor potential therapeutic amyloid clearance in AD model mice in vivo and with further development could be the basis for plaque detection in AD patients.
Supported by NIH grants AG20245, NS38461 and AG17617
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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